3-AMINO-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE

Base Information

• Chemical Name: 3-AMINO-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE
• CAS No.: 43012-47-1
• Molecular Formula: C8H8N2O.ClH
• Molecular Weight: 184.625
• Mol file: 43012-47-1.mol

Synonyms:

Chemical Property of 3-AMINO-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

3-amino-1,3-dihydro-2H-indol-2-onehydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of 3-AMINO-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE

There total 2 articles about 3-AMINO-1,3-DIHYDRO-2H-INDOL-2-ONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(hydroxyimino)indolin-2-one (607-28-3,73859-64-0,73859-66-2) → 3-amino-2-indolinone hydrochloride (43012-47-1)

Guidance literature:

3-(hydroxyimino)indolin-2-one; With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 4h;

With hydrogenchloride;

DOI:10.1055/s-0039-1691597

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 3-amino-2-indolinone hydrochloride (43012-47-1)

Guidance literature:

Reference yield: 97.0%

3-amino-2-indolinone hydrochloride (43012-47-1) + benzaldehyde (100-52-7) + 1,3-diphenyl-2-propynone (7338-94-5) → (2R,5R)-4-benzoyl-3,5-diphenyl-1,5-dihydrospiro[pyrrol-2,3’-oxindole]

Guidance literature:

With (R)‐3,3′‐bis(9‐phenanthryl)‐1,1′‐binaphthalene‐2,2′‐diyl hydrogen phosphate; sodium hydrogencarbonate; magnesium sulfate; In dichloromethane; at 25 ℃; for 65h; stereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7cc01653k

upstream raw materials:

indole-2,3-dione

3-(hydroxyimino)indolin-2-one

Downstream raw materials:

isoindigo