1-benzyl-1H-indazole

Base Information

• Chemical Name: 1-benzyl-1H-indazole
• CAS No.: 43120-25-8
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• European Community (EC) Number: 817-964-0
• Nikkaji Number: J487.981C
• ChEMBL ID: CHEMBL1575672
• Mol file: 43120-25-8.mol

Synonyms:1-benzyl-1H-indazole;1-benzylindazole;43120-25-8;MLS000107727;Cambridge id 5661529;SCHEMBL248214;CHEMBL1575672;HMS2491B18;AKOS003644534;CCG-276005;SMR000103692;EN300-18311;AB00092274-01;SR-01000216260;SR-01000216260-1;Z57842844

Chemical Property of 1-benzyl-1H-indazole

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 208.100048391
• Heavy Atom Count: 16
• Complexity: 223

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C=N2

Technology Process of 1-benzyl-1H-indazole

There total 16 articles about 1-benzyl-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-benzyl-2-(diphenylmethylene)-1-(2-(((diphenylmethylene)hydrazono)methyl)phenyl)hydrazine → 1-benzyl-1H-indazole (43120-25-8)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; water; at 100 ℃; for 0.5h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.tet.2014.07.092

Reference yield: 90.0%

benzimidazole (271-44-3) + benzyl chloride (100-44-7) → 1-benzyl-1H-indazole (43120-25-8)

Guidance literature:

With cesium fluoride; In acetonitrile; for 48h; Heating;

DOI:10.1016/S0040-4020(01)00989-9

Reference yield: 83.0%

C24H24N2 → 1-benzyl-1H-indazole (43120-25-8)

Guidance literature:

With maleiimide; In 1,2-dichloro-benzene; at 180 ℃;

DOI:10.1021/acscatal.9b05177

upstream raw materials:

benzimidazole

benzyl chloride

AF 1311TS

iodomethylbenzene

Downstream raw materials:

benzimidazole

2-chloroquinazoline

2-phenylquinazoline

1-benzyl-3-(5-methoxycarbonyl-furan-2-yl)-1H-indazole