2-Phenylquinazoline

Base Information

• Chemical Name: 2-Phenylquinazoline
• CAS No.: 25855-20-3
• Molecular Formula: C14H10N2
• Molecular Weight: 206.247
• DSSTox Substance ID: DTXSID90877389
• Nikkaji Number: J795.311I
• Wikidata: Q82859178
• Mol file: 25855-20-3.mol

Synonyms:2-phenylquinazoline

Chemical Property of 2-Phenylquinazoline

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 206.084398327
• Heavy Atom Count: 16
• Complexity: 223

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC3=CC=CC=C3C=N2

Technology Process of 2-Phenylquinazoline

There total 131 articles about 2-Phenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzaldehyde (100-52-7) + 2-amino-1-benzylamine (4403-69-4) → 2-phenylquinazoline (25855-20-3)

Guidance literature:

With 9-azabicyclo<3.3.1>nonane-N-oxyl; oxygen; potassium hydroxide; In toluene; at 80 ℃; for 11h;

DOI:10.1002/ejoc.201700384

Reference yield: 95.0%

2-Aminobenzyl alcohol (5344-90-1) + benzonitrile (100-47-0) → 2-phenylquinazoline (25855-20-3)

Guidance literature:

With potassium tert-butylate; cobalt(II) diacetate tetrahydrate; In tert-Amyl alcohol; at 95 ℃; for 24h; Temperature; Reagent/catalyst; Inert atmosphere;

Reference yield: 93.0%

2-Aminobenzyl alcohol (5344-90-1) + benzaldehyde (100-52-7) → 2-phenylquinazoline (25855-20-3)

Guidance literature:

With [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; cerium(III) nitrate hexahydrate; oxygen; ammonium chloride; copper(l) chloride; potassium hydroxide; In acetonitrile; at 30 - 80 ℃; for 48h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/jo401908g

upstream raw materials:

2-phenyl-5,6,7,8-tetrahydroquinazoline

2-phenylquinazoline-4-carboxylic acid

N-(2-formylphenyl)benzamide

N-(2-aminobenzyl)benzamide

Downstream raw materials:

N₁,N₃-bis(3,5-bis(trifluoromethyl)phenyl)-2-(quinazolin-2-yl)benzene-1,3-diamine

C₂₃H₁₇⁽²⁾HN₂O

(E)-4-(4-methoxystyryl)-2-phenylquinazoline

(E)-2-phenyl-4-styrylquinazoline

Refernces

• 1、 Luo, Lan,Liu, Hongqiang,Zeng, Wei,Hu, Wenkang,Wang, Dawei. "BTP-Rh@g-C3N4 as an efficient recyclable catalyst for dehydrogenation and borrowing hydrogen reactions". . . Retrieved 2021/11/16.
• 2、 Kaur, Lovjot,Kaur, Harpreet,Kumar, Manoj,Bhalla, Vandana. "Type I ‘Lighted Metal-free’ Photosensitizing Assemblies of Phenazine for Aerobic Oxidative Transformations". supporting information. p. 4179 - 4186. Retrieved 2021/11/23.