4-[(chloroacetyl)amino]-2-hydroxybenzoic acid

Base Information

• Chemical Name: 4-[(chloroacetyl)amino]-2-hydroxybenzoic acid
• CAS No.: 14463-22-0
• Molecular Formula: C9H8 Cl N O4
• Molecular Weight: 229.6171
• Mol file: 14463-22-0.mol

Synonyms:Benzoicacid, 4-[(chloroacetyl)amino]-2-hydroxy- (9CI); Salicylic acid,4-(2-chloroacetamido)- (8CI); NSC 55322; p-N-Chloroacetylaminosalicylic acid

Chemical Property of 4-[(chloroacetyl)amino]-2-hydroxybenzoic acid

Chemical Property:

• Vapor Pressure: 9.44E-11mmHg at 25°C
• Boiling Point: 498.4°Cat760mmHg
• Flash Point: 255.2°C
• Density: 1.585g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(chloroacetyl)amino]-2-hydroxybenzoic acid

There total 3 articles about 4-[(chloroacetyl)amino]-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-Aminosalicylic acid (65-49-6) + chloroacetyl chloride (79-04-9) → 4-(2-chloro-acetylamino)-2-hydroxy-benzoic acid (14463-22-0)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1016/j.tetlet.2006.06.090

Reference yield:

sodium p-aminosalicylate (133-10-8) + Chloroacetic anhydride (541-88-8) → 4-(2-chloro-acetylamino)-2-hydroxy-benzoic acid (14463-22-0)

Guidance literature:

With sodium acetate;

Reference yield:

→ 4-(2-chloro-acetylamino)-2-hydroxy-benzoic acid (14463-22-0)

Guidance literature:

p-Aminosalicylsaeure, Monochloressigsaeurechlorid;

upstream raw materials:

4-Aminosalicylic acid

chloroacetyl chloride

sodium p-aminosalicylate

Chloroacetic anhydride

Downstream raw materials:

4-Iodacetamidosalicylsaeure

[(4-carboxy-3-hydroxy-phenylcarbamoyl)-methyl]-trimethyl-ammonium; chloride