1-Bromo-3-(difluoromethoxy)-5-fluorobenzene

Base Information

• Chemical Name: 1-Bromo-3-(difluoromethoxy)-5-fluorobenzene
• CAS No.: 433939-28-7
• Molecular Formula: C7H4BrF3O
• Molecular Weight: 241.007
• Hs Code.: 2909309090
• Mol file: 433939-28-7.mol

Synonyms:1-bromo-3-(difluoromethoxy)-5-fluorobenzene;

Chemical Property of 1-Bromo-3-(difluoromethoxy)-5-fluorobenzene

Chemical Property:

• PSA: 9.23000
• LogP: 3.18960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-3-(difluoromethoxy)-5-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Bromo-3-(difluoromethoxy)-5-fluorobenzene

There total 3 articles about 1-Bromo-3-(difluoromethoxy)-5-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-bromo-5-fluorophenol (433939-27-6) + Chlorodifluoromethane (75-45-6) → (3-bromo-5-fluorophenyl)difluoromethyl ether (433939-28-7)

Guidance literature:

With potassium hydroxide; In water; isopropyl alcohol; at 20 - 85 ℃; for 18h;

Reference yield: 59.9%

3-bromo-5-fluorophenol (433939-27-6) + diethyl (bromodifluoromethyl)phosphonate (65094-22-6) → (3-bromo-5-fluorophenyl)difluoromethyl ether (433939-28-7)

Guidance literature:

With potassium hydroxide; In water; acetonitrile; at -78 - 20 ℃; for 0.333333h; Inert atmosphere;

Reference yield: 55.6%

3-bromo-5-fluorophenol (433939-27-6) + sodium chlorodifluoroacetate (1895-39-2) → (3-bromo-5-fluorophenyl)difluoromethyl ether (433939-28-7)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 4h;

upstream raw materials:

3-bromo-5-fluorophenol

Chlorodifluoromethane

sodium chlorodifluoroacetate

diethyl (bromodifluoromethyl)phosphonate

Downstream raw materials:

1-fluoro-3-difluoromethoxy-5-vinylbenzene

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