Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 4,6,7,8-tetrahydro-8-methyl-4-oxo-6-[(phenylamino)carbonyl]-3-[[(phenyl methoxy)carbonyl][[3-(trifluoromethyl)phenyl]methyl]amino]-, phenylmethyl ester, (6S,8S)-

Base Information

Chemical Name:Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 4,6,7,8-tetrahydro-8-methyl-4-oxo-6-[(phenylamino)carbonyl]-3-[[(phenyl methoxy)carbonyl][[3-(trifluoromethyl)phenyl]methyl]amino]-, phenylmethyl ester, (6S,8S)-
CAS No.:437761-33-6
Molecular Formula:C40H35F3N4O6
Molecular Weight:724.736
Hs Code.:

Pyrrolo[1,2-a]pyrimidine-8-acetic acid,
4,6,7,8-tetrahydro-8-methyl-4-oxo-6-[(phenylamino)carbonyl]-3-[[(phenyl
methoxy)carbonyl][[3-(trifluoromethyl)phenyl]methyl]amino]-,
phenylmethyl ester, (6S,8S)-

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Chemical Property of Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 4,6,7,8-tetrahydro-8-methyl-4-oxo-6-[(phenylamino)carbonyl]-3-[[(phenyl methoxy)carbonyl][[3-(trifluoromethyl)phenyl]methyl]amino]-, phenylmethyl ester, (6S,8S)-

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Technology Process of Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 4,6,7,8-tetrahydro-8-methyl-4-oxo-6-[(phenylamino)carbonyl]-3-[[(phenyl methoxy)carbonyl][[3-(trifluoromethyl)phenyl]methyl]amino]-, phenylmethyl ester, (6S,8S)-

There total 1 articles about Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 4,6,7,8-tetrahydro-8-methyl-4-oxo-6-[(phenylamino)carbonyl]-3-[[(phenyl methoxy)carbonyl][[3-(trifluoromethyl)phenyl]methyl]amino]-, phenylmethyl ester, (6S,8S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 437761-32-5
((6S,8S)-6-(Anilinocarbonyl)-3-{[(benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetic acid

: 437761-33-6
benzyl ((6S,8S)-6-(anilinocarbonyl)-3-{[(benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetate

Guidance literature:: With caesium carbonate;
DOI:10.1016/S0960-894X(03)00022-2

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 437761-33-6
benzyl ((6S,8S)-6-(anilinocarbonyl)-3-{[(benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetate

: 437761-34-7
[3-[benzyloxycarbonyl-(3-trifluoromethyl-benzyl)-amino]-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic acid benzyl ester

Guidance literature:: With dmap; In acetonitrile;
DOI:10.1016/S0960-894X(03)00022-2

Reference yield:

: 437761-33-6
benzyl ((6S,8S)-6-(anilinocarbonyl)-3-{[(benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetate

: 437761-37-0
((6S,8S)-6-[({(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]propyl}amino)carbonyl]-8-methyl-4-oxo-3-{[3-(trifluoromethyl)benzyl]amino}-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / DMAP / acetonitrile

2: 100 percent / aq. H₂O₂; LiOH

3: 52 percent / EDCI; HOAt

4: 100 percent / H₂ / Pd/C / methanol

With dmap; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1016/S0960-894X(03)00022-2