Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 6-carboxy-4,6,7,8-tetrahydro-8-methyl-4-oxo-3-[[(phenylmethoxy)carbon yl][[3-(trifluoromethyl)phenyl]methyl]amino]-, a-(phenylmethyl) ester, (6S,8S)-

Base Information

Chemical Name:Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 6-carboxy-4,6,7,8-tetrahydro-8-methyl-4-oxo-3-[[(phenylmethoxy)carbon yl][[3-(trifluoromethyl)phenyl]methyl]amino]-, a-(phenylmethyl) ester, (6S,8S)-
CAS No.:437761-35-8
Molecular Formula:C₃₄H₃₀F₃N₃O₇
Molecular Weight:649.623
Hs Code.:

Pyrrolo[1,2-a]pyrimidine-8-acetic acid,
6-carboxy-4,6,7,8-tetrahydro-8-methyl-4-oxo-3-[[(phenylmethoxy)carbon
yl][[3-(trifluoromethyl)phenyl]methyl]amino]-, a-(phenylmethyl) ester,
(6S,8S)-

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Chemical Property of Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 6-carboxy-4,6,7,8-tetrahydro-8-methyl-4-oxo-3-[[(phenylmethoxy)carbon yl][[3-(trifluoromethyl)phenyl]methyl]amino]-, a-(phenylmethyl) ester, (6S,8S)-

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Technology Process of Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 6-carboxy-4,6,7,8-tetrahydro-8-methyl-4-oxo-3-[[(phenylmethoxy)carbon yl][[3-(trifluoromethyl)phenyl]methyl]amino]-, a-(phenylmethyl) ester, (6S,8S)-

There total 5 articles about Pyrrolo[1,2-a]pyrimidine-8-acetic acid, 6-carboxy-4,6,7,8-tetrahydro-8-methyl-4-oxo-3-[[(phenylmethoxy)carbon yl][[3-(trifluoromethyl)phenyl]methyl]amino]-, a-(phenylmethyl) ester, (6S,8S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 437761-34-7
[3-[benzyloxycarbonyl-(3-trifluoromethyl-benzyl)-amino]-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic acid benzyl ester

: 437761-35-8
(6S,8S)-3-{[(Benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-[2-(benzyloxy)-2-oxoethyl]-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide;
DOI:10.1016/S0960-894X(03)00022-2

Reference yield:

: 100-39-0
benzyl bromide

: 437761-35-8
(6S,8S)-3-{[(Benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-[2-(benzyloxy)-2-oxoethyl]-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃

2: 93 percent / DMAP / acetonitrile

3: 100 percent / aq. H₂O₂; LiOH

With dmap; lithium hydroxide; dihydrogen peroxide; caesium carbonate; In acetonitrile;
DOI:10.1016/S0960-894X(03)00022-2

Reference yield:

: 437761-32-5
((6S,8S)-6-(Anilinocarbonyl)-3-{[(benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetic acid

: 437761-35-8
(6S,8S)-3-{[(Benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-[2-(benzyloxy)-2-oxoethyl]-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃

2: 93 percent / DMAP / acetonitrile

3: 100 percent / aq. H₂O₂; LiOH

With dmap; lithium hydroxide; dihydrogen peroxide; caesium carbonate; In acetonitrile;
DOI:10.1016/S0960-894X(03)00022-2