3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3S)-

Base Information

Chemical Name:3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3S)-
CAS No.:441003-77-6
Molecular Formula:C28H39N3O3
Molecular Weight:465.636
Hs Code.:

3-Isoquinolinecarboxamide,
1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,
4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3S)-

Synonyms:

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Chemical Property of 3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3S)-

Chemical Property:

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Technology Process of 3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3S)-

There total 4 articles about 3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[1-(2S-Amino-3-methylbutyl)-3R,4R-dimethyl-4-piperidinyl]phenol

: Boc-D-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 441003-77-6,361444-66-8
(3S)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide

Guidance literature:: With triethanolamine; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform;

Reference yield:

: (S)-7-Hydroxy-3-{(S)-1-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 441003-77-6,361444-66-8
(3S)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at -20 - 20 ℃;
DOI:10.1021/jm030094y

Reference yield:

: 142335-42-0
(3S)-2-(tert-butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid

: 441003-77-6,361444-66-8
(3S)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: BOP; Et₃N / tetrahydrofuran / 2 h / 20 °C

2: TFA / CH₂Cl₂ / -20 - 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030094y