Carbamic acid, [(1S,3R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-1-[[(4S)-2-oxo -4-phenyl-3-oxazolidinyl]carbonyl]butyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S,3R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-1-[[(4S)-2-oxo -4-phenyl-3-oxazolidinyl]carbonyl]butyl]-, 1,1-dimethylethyl ester
CAS No.:445483-92-1
Molecular Formula:C36H46N2O6Si
Molecular Weight:630.857
Hs Code.:

Carbamic acid,
[(1S,3R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-1-[[(4S)-2-oxo
-4-phenyl-3-oxazolidinyl]carbonyl]butyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, [(1S,3R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-1-[[(4S)-2-oxo -4-phenyl-3-oxazolidinyl]carbonyl]butyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1S,3R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-1-[[(4S)-2-oxo -4-phenyl-3-oxazolidinyl]carbonyl]butyl]-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [(1S,3R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-3-methyl-1-[[(4S)-2-oxo -4-phenyl-3-oxazolidinyl]carbonyl]butyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 445483-91-0
(4S)-3-[(2S,4R)-2-azido-5-tert-butyldiphenylsilyloxy-4-methylpentanoyl]-4-phenyloxazolidin-2-one

: 445483-92-1
(4S)-3-[(2S,4R)-2-tert-butoxycarbonylamino-5-tert-butyldiphenylsilyloxy-4-methylpentanoyl]-4-phenyloxazolidin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 15h;
DOI:10.1002/ejoc.200600154

Reference yield:

: 95514-03-7
(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester

: 445483-92-1
(4S)-3-[(2S,4R)-2-tert-butoxycarbonylamino-5-tert-butyldiphenylsilyloxy-4-methylpentanoyl]-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 93 percent / DIBAL-H / toluene; diethyl ether / 1.25 h / -80 °C

2.1: 70 percent / (i-Pr)2NEt; LiCl / acetonitrile / 24 h / 20 °C

3.1: 100 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

4.1: KHMDS / tetrahydrofuran; toluene / 0.67 h / -80 °C

4.2: trisyl azide / tetrahydrofuran; toluene / 0.07 h / -80 °C

4.3: 68 percent / acetic acid / tetrahydrofuran; toluene / -80 - 20 °C

5.1: 99 percent / H₂ / Pd/C / ethyl acetate / 15 h / 20 °C

With hydrogen; potassium hexamethylsilazane; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; toluene; acetonitrile;
DOI:10.1002/ejoc.200600154

Reference yield:

: 445483-89-6
(4S)-3-[(4R,2E)-5-tert-butyldiphenylsilyloxy-4-methyl-2-pentenoyl]-4-phenyloxazolidin-2-one

: 445483-92-1
(4S)-3-[(2S,4R)-2-tert-butoxycarbonylamino-5-tert-butyldiphenylsilyloxy-4-methylpentanoyl]-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

2.1: KHMDS / tetrahydrofuran; toluene / 0.67 h / -80 °C

2.2: trisyl azide / tetrahydrofuran; toluene / 0.07 h / -80 °C

2.3: 68 percent / acetic acid / tetrahydrofuran; toluene / -80 - 20 °C

3.1: 99 percent / H₂ / Pd/C / ethyl acetate / 15 h / 20 °C

With hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1002/ejoc.200600154