Technology Process of (6R,8S)-2,2,6,9,12,12-hexamethyl-10-oxo-3,3-diphenyl-4,11-dioxa-9-aza-3-silatridecane-8-carboxylic acid
There total 13 articles about (6R,8S)-2,2,6,9,12,12-hexamethyl-10-oxo-3,3-diphenyl-4,11-dioxa-9-aza-3-silatridecane-8-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(6R,8S)-2,2,6,12,12-pentamethyl-10-oxo-3,3-diphenyl-4,11-dioxa-9-aza-3-silatridecane-8-carboxylic acid;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran;
at 20 ℃;
for 48h;
Inert atmosphere;
DOI:10.1016/j.tetasy.2011.08.026
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: LiCl; i-Pr2NEt / acetonitrile / 20 °C
2.1: 97 percent / H2 / 5 percent Pd-C / ethyl acetate
3.1: KHMDS / tetrahydrofuran / -78 °C
3.2: trisyl azide / tetrahydrofuran / -78 °C
3.3: 82 percent / AcOH / tetrahydrofuran / 20 °C
4.1: H2 / 5 percent Pd-C / ethyl acetate
5.1: ethyl acetate
6.1: aq. LiOH; 30 percent aq. H2O2 / tetrahydrofuran
7.1: NaH / tetrahydrofuran / 0 - 20 °C
With
lithium hydroxide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; ethyl acetate; acetonitrile;
1.1: Horner-Emmons reaction;
DOI:10.1016/S0040-4039(02)00607-X
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: DIBAL / diethyl ether / -78 °C
2.1: LiCl; i-Pr2NEt / acetonitrile / 20 °C
3.1: 97 percent / H2 / 5 percent Pd-C / ethyl acetate
4.1: KHMDS / tetrahydrofuran / -78 °C
4.2: trisyl azide / tetrahydrofuran / -78 °C
4.3: 82 percent / AcOH / tetrahydrofuran / 20 °C
5.1: H2 / 5 percent Pd-C / ethyl acetate
6.1: ethyl acetate
7.1: aq. LiOH; 30 percent aq. H2O2 / tetrahydrofuran
8.1: NaH / tetrahydrofuran / 0 - 20 °C
With
lithium hydroxide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; lithium chloride;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethyl acetate; acetonitrile;
2.1: Horner-Emmons reaction;
DOI:10.1016/S0040-4039(02)00607-X
