L 345

Base Information

• Chemical Name: L 345
• CAS No.: 121809-82-3
• Molecular Formula: C17H15 Cl3 N2 O4
• Molecular Weight: 417.67
• Mol file: 121809-82-3.mol

Synonyms:L 345

Chemical Property of L 345

Chemical Property:

• Vapor Pressure: 5.25E-10mmHg at 25°C
• Boiling Point: 479.6°Cat760mmHg
• Flash Point: 243.8°C
• PSA: 91.15000
• Density: 1.524g/cm³
• LogP: 5.61940

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L 345

There total 9 articles about L 345 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-aminophenoxy)-2-methyl propionic acid (117011-70-8) + 3,4,5-trichlorophenyl isocyanate (35753-93-6) → 4-(3,4,5-trichlorophenylureido)phenoxyisobutyric acid (121809-82-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00130a021

Reference yield:

(4-hydroxyphenyl)carbamic acid ethyl ester (7159-95-7) → 4-(3,4,5-trichlorophenylureido)phenoxyisobutyric acid (121809-82-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 percent / NaOH / 4 h / Heating

2: 87 percent / 10percent KOH / 0.5 h / Heating

3: 90 percent / 2 N NaOH / tetrahydrofuran

With potassium hydroxide; sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00130a021

Reference yield:

4-amino-phenol (123-30-8) → 4-(3,4,5-trichlorophenylureido)phenoxyisobutyric acid (121809-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Ambient temperature

2: NaOH / Heating

With sodium hydroxide; In pyridine;

DOI:10.1021/jm00130a021

upstream raw materials:

chloroform

acetone

2-(4-aminophenoxy)-2-methyl propionic acid

3,4,5-trichlorophenyl isocyanate

Refernces