2'-chloroflavone

Base Information

• Chemical Name: 2'-chloroflavone
• CAS No.: 116115-48-1
• Molecular Formula: C15H9 Cl O2
• Molecular Weight: 256.688
• Mol file: 116115-48-1.mol

Synonyms:2'-Chloroflavone

Chemical Property of 2'-chloroflavone

Chemical Property:

• Boiling Point: 398.6°Cat760mmHg
• Flash Point: 167.7°C
• PSA: 30.21000
• Density: 1.342g/cm³
• LogP: 4.11340

Purity/Quality:

2'-CHLOROFLAVONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-chloroflavone

There total 16 articles about 2'-chloroflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chloro-benzaldehyde (89-98-5) + 1-phenyl-2-hydroxyethanone (582-24-1) → 2'-Chloroflavone (116115-48-1)

Guidance literature:

With 1-propyl-3-methylimidazolium vanadate; oxygen; In ethylene glycol; at 60 ℃; for 3h; under 750.075 Torr;

Reference yield: 91.0%

1-(2-hydroxyphenyl)-3-(2-chlorophenyl)propane-1,3-dione (60121-60-0) → 2'-Chloroflavone (116115-48-1)

Guidance literature:

With gallium(III) triflate; In nitromethane; at 80 ℃; for 2.5h;

DOI:10.3184/030823409X396409

Reference yield: 88.0%

2-chloro-2'-hydroxychalcone (36136-61-5) → 2'-Chloroflavone (116115-48-1)

Guidance literature:

With iodine; In dimethyl sulfoxide; for 0.0333333h; Microwave irradiation;

upstream raw materials:

2,3-dihydro-2-(2,-chlorophenyl)-4H-1-benzopyran-4-one

(trimethylsilyl)methylenetriphenylphosphorane

C₁₄H₉O₄ClC₆H₁₄Si

1-(2-hydroxyphenyl)-3-(2-chlorophenyl)propane-1,3-dione

Downstream raw materials:

2-(2-chlorophenyl)-3-methyl-4H-chromen-4-one

Refernces

• 1、 Song, Zhibin,Huang, Wei,Zhou, Yan,Tian, Zi-Qi,Li, Zhang-Min,Tao, Duan-Jian. "Thermally regulated molybdate-based ionic liquids toward molecular oxygen activation for one-pot oxidative cascade catalysis". . p. 103 - 109. Retrieved 2020.
• 2、 Ramakrishna, Boddu S.,Rao, Maddali L. N.. "Rh-Catalyzed aldehydic C-H alkynylation and annulation". . p. 1402 - 1411. Retrieved 2020/03/03.