60121-60-0Relevant academic research and scientific papers
A New Protocol for Total Synthesis of Natural Product Frutinone A and Its Derivatives
Lei, Kang,Sun, Dong-Wei,Tao, Yuan-Yuan,Xu, Xiao-Hua
, p. 98 - 106 (2016/01/26)
A new protocol for total synthesis of natural product frutinone A was accomplished in three steps by using inexpensive 2′-hydroxyacetophenone as starting material. The key intermediate 3-(2-chlorobenzoyl)-4-hydroxycoumarin was synthesized in one pot through Baker-Venkataraman rearrangement of 2-acetylphenyl 2-chlorobenzoate followed by introduction of methyl chloroformate under basic conditions. Then, base-promoted intramolecular nucleophilic substitution reaction of 3-(2-chlorobenzoyl)-4-hydroxycoumarin provided frutinone A in excellent yield. The synthetic route features good yield, transition metal-free and mild reaction conditions, and high tolerance for functionality, thereby allowing easy substitutions around the frutinone A core.
Synthesis and reactivity of 1-aryl-9h-thieno[3,4-b]chromon-9-ones
Krayushkin, Mikhail M.,Levchenko, Konstantin S.,Yarovenko, Vladimir N.,Christoforova, Ludmila V.,Barachevsky, Valery A.,Puankov, Yury A.,Valova, Tatyana M.,Kobeleva, Olga I.,Lyssenko
experimental part, p. 2267 - 2277 (2011/04/23)
Methods were developed for the synthesis of 1-aryl-9H-thieno[3,4-b]chromon- 9-ones based on the reaction of bromo and dibromo derivatives of 2-methyl-4H-chromon-4-one with thioacetamide in DMF. The thienochromones were modified and their fluorescence prop
2-(2'-Hydroxyphenyl)-4-aryl-1,5-benzodiazepines as CNS active agents
Srivastava,Satsangi,Kishore
, p. 1512 - 1514 (2007/10/02)
1-Aryl-3(2'-hydroxyphenyl)-propane-1,3-diones (III) have been prepared by the Baker-Venkataraman transformation of the corresponding 2-substituted benzoyloxyacetophenones (II). The aforesaid propane-1,3-diones (III) were condensed with o-phenylene diamine
