picolyl benzoate

Base Information

• Chemical Name: picolyl benzoate
• CAS No.: 46721-93-1
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Mol file: 46721-93-1.mol

Synonyms:picolyl benzoate;benzoic acid-[4]pyridylmethyl ester;Benzoesaeure-[4]pyridylmethylester;4-picolyl benzoate;

Chemical Property of picolyl benzoate

Chemical Property:

• PSA: 39.19000
• LogP: 2.43860

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of picolyl benzoate

There total 10 articles about picolyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

pyridine-4-methanol (586-95-8) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → pyridin-4-ylmethyl benzoate (46721-93-1)

Guidance literature:

With sodium t-butanolate; In tert-Amyl alcohol; at 120 ℃; for 18h; Schlenk technique;

DOI:10.1039/c4ra04618h

Reference yield: 66.0%

pyridine-4-methanol (586-95-8) + benzoic acid (65-85-0,8013-63-6) → pyridin-4-ylmethyl benzoate (46721-93-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b03019

Reference yield: 60.0%

pyridine-4-methanol (586-95-8) + benzoyl chloride (98-88-4) → pyridin-4-ylmethyl benzoate (46721-93-1)

Guidance literature:

With triethylamine; In benzene; at 20 ℃; for 16h;

DOI:10.1021/jo049501j

upstream raw materials:

pyridine-4-methanol

benzoyl chloride

4-methylpyridine-1-oxide

benzoic acid anhydride

Downstream raw materials:

4-pyridinemethanol hydrochloride

benzoic acid

Refernces

• 1、 Joshi, Madhur S.,Pigge, F.Christopher. "Construction of 1,2,4-Triazole Derivatives via Cyclocondensation of Alkylidene Dihydropyridines and Aryldiazonium Salts". supporting information. p. 5916 - 5919. Retrieved 2016/11/29.
• 2、 Hasník, Zbyněk,?ilhár, Peter,Hocek, Michal. "Hydroxymethylations of aryl halides by Pd-catalyzed cross-couplings with (benzoyloxy)methylzinc iodide - Scope and limitations of the reaction". . p. 543 - 546. Retrieved 2008/12/22.