2-Propanone, 1,3-bis(1-methyl-2-pyrrolidinyl)-

Base Information

Chemical Name:2-Propanone, 1,3-bis(1-methyl-2-pyrrolidinyl)-
CAS No.:46727-05-3
Molecular Formula:C13H24N2O
Molecular Weight:
Hs Code.:
Mol file:46727-05-3.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propanone, 1,3-bis(1-methyl-2-pyrrolidinyl)-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-Propanone, 1,3-bis(1-methyl-2-pyrrolidinyl)-

There total 12 articles about 2-Propanone, 1,3-bis(1-methyl-2-pyrrolidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 468732-35-6,80408-57-7
dihydrocuscohydrine

: 46727-05-3
1,3-bis-(1-methyl-pyrrolidin-2-yl)-propan-2-one

Guidance literature:: With jones' reagent; In acetone; at 0 ℃; for 2h;
DOI:10.1021/jo025666l

Reference yield:

: 872-50-4,26138-58-9
1-methyl-pyrrolidin-2-one

: 542-05-2
acetonedicarboxylic acid

: 3-(N-methyl-2-pyrrolidinyl)hygrine

: 4-(N-methyl-2-pyrrolidinyl)hygrine

: 46727-05-3
1,3-bis-(1-methyl-pyrrolidin-2-yl)-propan-2-one

Guidance literature:: 1-methyl-pyrrolidin-2-one; With lithium aluminium tetrahydride; In diethyl ether; for 1h;

acetonedicarboxylic acid; With sodium hydroxide; In phosphate buffer; at 20 ℃; for 40h; pH=7; Further stages.;
DOI:10.1016/j.phytochem.2005.04.027

Reference yield:

: 134734-52-4
(1R,4S,6S)-4-acetoxy-6-[(tert-butyldimethylsilyl)oxy]-2-cyclohepten-1-ol

: 46727-05-3
1,3-bis-(1-methyl-pyrrolidin-2-yl)-propan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 82 percent / diisopropylazodicarboxylate; PPh₃ / tetrahydrofuran / 18 h / 20 °C

2.1: 95 percent / KCN / methanol / 18 h / 20 °C

3.1: 85 percent / mesyl chloride; pyridine / 18 h / 20 °C

4.1: 86 percent / K₂CO₃ / acetonitrile / 18 h / 70 °C

5.1: K₂CO₃; PhSH / dimethylformamide / 0.5 h / 70 °C

5.2: 82 percent / dimethylformamide / 2 h / 20 °C

6.1: [Ru(PCy₃)2Cl₂=CHPh] / CH₂Cl₂ / 36 h / Heating

6.2: 72 percent / H₂ / 10percent Pd/C / ethanol / 20 °C

7.1: 92 percent / LiAlH₄ / diethyl ether / 0.75 h / 20 °C

8.1: 89 percent / conc. HCl / ethanol

9.1: 73 percent / Jones' reagent / acetone / 2 h / 0 °C

With pyridine; hydrogenchloride; potassium cyanide; lithium aluminium tetrahydride; Grubbs catalyst first generation; jones' reagent; di-isopropyl azodicarboxylate; potassium carbonate; methanesulfonyl chloride; thiophenol; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; 1.1: Mitsunobu reaction / 9.1: Jones oxidation;
DOI:10.1021/jo025666l