Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]butyl]-N-(phenylmethyl)-

Base Information

• Chemical Name: Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]butyl]-N-(phenylmethyl)-
• CAS No.: 467471-53-0
• Molecular Formula: C27H41ClN2O3SSi
• Molecular Weight: 537.239

Synonyms:

Chemical Property of Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]butyl]-N-(phenylmethyl)-

Chemical Property:

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Safty Information:

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Useful:

Technology Process of Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]butyl]-N-(phenylmethyl)-

There total 4 articles about Acetamide, 2-chloro-N-[(1S,2R)-1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-[[( S)-(4-methylphenyl)sulfinyl]amino]butyl]-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

chloroacetyl chloride (79-04-9) + (+)-(1R,2S,SS)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-ethylprop-1-yl]-p-tolylsulfinamide (467471-51-8) → (+)-N-benzyl-N-[(1S,2R,SS)-1-(t-butyldimethylsilyloxymethyl)-2-(p-tolylsulfinylamino)but-1-yl]-2-chloroacetamide (467471-53-0)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 0 - 20 ℃; for 2h;

DOI:10.1055/s-2002-25336

Reference yield:

(+)-(2S,3R,SS)-2-(benzylamino)-3-(p-tolylsulfinylamino)pentan-1-ol (467471-29-0) → (+)-N-benzyl-N-[(1S,2R,SS)-1-(t-butyldimethylsilyloxymethyl)-2-(p-tolylsulfinylamino)but-1-yl]-2-chloroacetamide (467471-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / imidazole; DMAP / CH₂Cl₂ / 1.5 h / 20 °C

2: 82 percent / aq. NaHCO₃ / ethyl acetate / 0 - 20 °C

With 1H-imidazole; dmap; sodium hydrogencarbonate; In dichloromethane; ethyl acetate;

DOI:10.1021/jo052077h

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (+)-N-benzyl-N-[(1S,2R,SS)-1-(t-butyldimethylsilyloxymethyl)-2-(p-tolylsulfinylamino)but-1-yl]-2-chloroacetamide (467471-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / imidazole; DMAP / CH₂Cl₂ / 1.5 h / 20 °C

2: 82 percent / aq. NaHCO₃ / ethyl acetate / 0 - 20 °C

With 1H-imidazole; dmap; sodium hydrogencarbonate; In dichloromethane; ethyl acetate;

DOI:10.1021/jo052077h

upstream raw materials:

chloroacetyl chloride

(+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-ethylprop-1-yl]-p-tolylsulfinamide

tert-butyldimethylsilyl chloride

(+)-(2S,3R,S_S)-2-(benzylamino)-3-(p-tolylsulfinylamino)pentan-1-ol

Downstream raw materials:

(+)-(5R,6S,S_S)-1-benzyl-6-[(t-butyldimethylsilyloxy)methyl]-5-ethyl-4-(p-tolylsulfinyl)piperazin-2-one

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