5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]

Base Information

Chemical Name:5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]
CAS No.:1355460-55-7
Molecular Formula:C₅₆H₇₆N₁₀O₉
Molecular Weight:1033.28
Hs Code.:

Synonyms:5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]

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Chemical Property of 5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]

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Technology Process of 5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]

There total 5 articles about 5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1355460-33-1
5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis(pyrazolo[1,5-a]pyridine-3-carboxylic acid)

: 21103-33-3
4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine

: 1355460-55-7
5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2011.10.063

Reference yield:

: 1355460-23-9
methyl 5-bromomethylpyrazolo[1,5-a]pyridine-3-carboxylate

: 1355460-55-7
5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0 °C

1.2: 2 h / 20 °C

2.1: sodium hydroxide / methanol; water / 4 h / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With potassium hexamethylsilazane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.10.063

Reference yield:

: 112-60-7
Tetraethylene glycol

: 1355460-55-7
5,5'-(2,5,8,11,14-pentaoxapentadecane-1,15-diyl)bis[N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-3-carboxamide]

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0 °C

1.2: 2 h / 20 °C

2.1: sodium hydroxide / methanol; water / 4 h / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With potassium hexamethylsilazane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.10.063