5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

Base Information

• Chemical Name: 5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole
• CAS No.: 476473-97-9
• Molecular Formula: C8H5ClF2O2
• Molecular Weight: 206.576
• Mol file: 476473-97-9.mol

Synonyms:5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole;5-CHLOROMETHYL-2,2-DIFLUORO-BENZO[1,3]DIOXOLE;5-(CHLOROMETHYL)-2,2-DIFLUORO-2H-1,3-BENZODIOXOLE;5-chloromethyl-2,2-difluoro-1,3-benzodioxole;

Chemical Property of 5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

Chemical Property:

• PSA: 18.46000
• LogP: 2.74690

Purity/Quality:

99%, ^*data from raw suppliers

5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole is used to prepare substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles as TGF-β signal transduction inhibitors.

Technology Process of 5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

There total 8 articles about 5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2,2-difluoro-1,3-benzodioxol-5-yl)methanol (72768-97-9) → 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole (476473-97-9)

Guidance literature:

With thionyl chloride; dmap; In tert-butyl methyl ether; at 15 - 30 ℃;

Reference yield: 92.7%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,2-difluoro-1,3-benzodioxole (1583-59-1) → 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole (476473-97-9)

Guidance literature:

With hydrogenchloride; In water; at 25 ℃; for 5h; Temperature;

Reference yield:

(2,2-difluoro-1,3-benzodioxol-5-yl)methanol (72768-97-9) + tert-butyl methyl ether (1634-04-4) → 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole (476473-97-9)

Guidance literature:

With thionyl chloride; aq. NaOH; dmap; In water;

upstream raw materials:

(2,2-difluoro-1,3-benzodioxol-5-yl)methanol

tert-butyl methyl ether

5-bromo-2,2-difluoro-2H-1,3-benzodioxole

2,2-difluoro-1,3-benzodioxole-5-carboxylic acid

Downstream raw materials:

2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile

1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile

1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid

(R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide

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