4-(chloromethyl)-2-(4-nitrophenyl)-1,3-thiazole

Base Information

• Chemical Name: 4-(chloromethyl)-2-(4-nitrophenyl)-1,3-thiazole
• CAS No.: 4771-32-8
• Molecular Formula: C₁₀H₇ClN₂O₂S
• Molecular Weight: 254.697
• Mol file: 4771-32-8.mol

Synonyms:4-Chlormethyl-2-(4-nitro-phenyl)-thiazol;4-Chlormethyl-2-(4-nitrophenyl)thiazol;4-chloromethyl-2-(4-nitro-phenyl)-thiazole;

Chemical Property of 4-(chloromethyl)-2-(4-nitrophenyl)-1,3-thiazole

Chemical Property:

• PSA: 86.95000
• LogP: 3.98030

Purity/Quality:

95% ^*data from raw suppliers

4-(Chloromethyl)-2-(4-nitrophenyl)-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(chloromethyl)-2-(4-nitrophenyl)-1,3-thiazole

There total 3 articles about 4-(chloromethyl)-2-(4-nitrophenyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

1,3-Dichloroacetone (534-07-6) + 4-nitrothiobenzamide (26060-30-0,34496-30-5) → 4-chloromethyl-2-(4-nitrophenyl)-thiazole (4771-32-8)

Guidance literature:

In toluene; Reflux;

DOI:10.1021/jm401643m

Reference yield:

4-nitrobenzonitrile (619-72-7) → 4-chloromethyl-2-(4-nitrophenyl)-thiazole (4771-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetraphosphorus decasulfide / ethanol / 6.5 h / Reflux

2: toluene / Reflux

With tetraphosphorus decasulfide; In ethanol; toluene;

DOI:10.1021/jm401643m

Reference yield:

→ 4-chloromethyl-2-(4-nitrophenyl)-thiazole (4771-32-8)

Guidance literature:

/BRN= 183942/;

DOI:10.1021/ja01290a045

upstream raw materials:

4-nitrobenzonitrile

1,3-Dichloroacetone

4-nitrothiobenzamide

Downstream raw materials:

5-chloro-4-chloromethyl-2-(4-nitro-phenyl)-thiazole

5-bromo-4-chloromethyl-2-(4-nitro-phenyl)-thiazole

[2-(4-nitro-phenyl)-thiazol-4-yl]-methanol

5-bromo-2-(4-nitro-phenyl)-thiazole-4-carbaldehyde

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