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Cobametin

Base Information Edit
  • Chemical Name:Cobametin
  • CAS No.:13422-55-4
  • Molecular Formula:C63H91CoN13O14P
  • Molecular Weight:1344.46
  • Hs Code.:29362600
  • European Community (EC) Number:236-535-3
  • Wikipedia:Methylcobalamin
  • NCI Thesaurus Code:C173805
  • RXCUI:29421
  • Mol file:13422-55-4.mol
Cobametin

Synonyms:Methycobal;Cobamet;methylcobalamin;Methyl-B12;Mecobalamin;Mecobalamine;Cobametin;Vancomin;Cobalt-methylcobalamin;Methyl cobalamine;MBL-A;Mecobalamine [INN-French];Mecobalaminum [INN-Latin];Mecobalamina [INN-Spanish];Methyl vitamin B12;Adestolmin (TN);C63-H91-N13-O14-P.Co;13422-55-4;Methyl-5,6-dimethylbenzimidazolylcobalamin;Mecobalamin (JP17/USAN);E0302;Cobinamide, Co-methyl deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole;Cobinamide, Co-methyl derivative, hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole;D03246

Suppliers and Price of Cobametin
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Vitamin B12
  • 48Tests
  • $ 639.00
  • Usbiological
  • Vitamin B12
  • 200ul
  • $ 473.00
  • TRC
  • Mecobalamin
  • 250mg
  • $ 155.00
  • Sigma-Aldrich
  • Vitamin B12 ≥98%
  • 25 g
  • $ 1460.00
  • Sigma-Aldrich
  • Vitamin B12 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%
  • 250 mg
  • $ 62.40
  • Sigma-Aldrich
  • Vitamin B12 ≥98%
  • 250 mg
  • $ 59.90
  • Sigma-Aldrich
  • Vitamin B12 ≥98%
  • 500 mg
  • $ 77.40
  • Sigma-Aldrich
  • Methylcobalamin vitamin B
  • 25mg
  • $ 77.40
  • Sigma-Aldrich
  • Methylcobalamin vitamin B
  • 100mg
  • $ 115.00
  • Sigma-Aldrich
  • Vitamin B12 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%
  • 100 mg
  • $ 47.90
Total 248 raw suppliers
Chemical Property of Cobametin Edit
Chemical Property:
  • Appearance/Colour:dark red crystalline powder 
  • Melting Point:>190°C (dec.) 
  • PKA:pK1:7.64(+1) (25°C) 
  • PSA:463.87000 
  • LogP:7.19930 
  • Storage Temp.:−20°C 
  • Solubility.:DMSO (Slightly), Methanol (Sparingly), Water (Slightly) 
  • Water Solubility.:Partially soluble in cold water, hot water. 
  • Hydrogen Bond Donor Count:9
  • Hydrogen Bond Acceptor Count:20
  • Rotatable Bond Count:26
  • Exact Mass:1343.587800
  • Heavy Atom Count:92
  • Complexity:3140
Purity/Quality:

98% *data from raw suppliers

Vitamin B12 *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 24/25-36-26 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:[CH3-].CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=N6)C(=C7C(C(C(=N7)C=C8C(C(C(=N8)C(=C4[N-]5)C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3]
  • Isomeric SMILES:[CH3-].CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3C(C([C@@H](O3)CO)OP(=O)([O-])OC(C)CNC(=O)CC[C@@]\4([C@H](C5[C@]6([C@@]([C@@H](C(=N6)/C(=C\7/[C@@]([C@@H](C(=N7)/C=C\8/C([C@@H](C(=N8)/C(=C4\[N-]5)/C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[Co+3]
  • Recent ClinicalTrials:A Study in Patients With Amyotrophic Lateral Sclerosis (ALS)
  • Uses 1.It is used for the treatment of nervous system diseases, relieving pain and numbness, speeded relieving pain, improving pain caused by cervical spondylosis, treatment of sudden deafness, etc. 2.Methylcobalamin is a kind of endogenous coenzyme B12, participating in the one carbon unit cycle, playing an important role in the synthesis of methionine homocysteine methyl transfer reaction process. One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic). Histamine receptor, Alzheimer research
  • Description Methylcobalamin is an analog of vitamin B12 with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 μM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.
  • Physical properties Vitamin B12 is an octahedral cobalt complex consisting of a porphyrin-like, cobalt centered macroring (called a corrin ring or nucleus). The corrinoids are red, red orange, or yellow crystalline substances that show intense absorption spectra above 300 nm owing to the π–π transitions of the corrin nucleus. They are soluble in water and are fairly stable to heat but decompose at temperatures above ~210 °C without melting.Vitamin B12 reacts with ascorbic acid, resulting in the reduction and subsequent degradation of the former, which releases its cobalt atom as the free ion. Cobalamins are more stable in the presence of ascorbic acid but unstable to light
Technology Process of Cobametin

There total 2 articles about Cobametin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
cyanocobalamin; With sodium tetrahydroborate; cobalt(II) chloride; In water; butanone; at 30 - 50 ℃; for 1.66667 - 2.5h;
trimethyloxosulfonium bromide; In water; butanone; at 15 - 50 ℃;
Guidance literature:
With sodium tetrahydroborate; cobalt(II) chloride; In water; butanone; at 15 - 40 ℃;
Guidance literature:
In water; Electrolysis; electrolysis at 0.8 V at pH 7.2; not isolated, detected by UV and cyclic voltammetry;
DOI:10.1021/ic00139a062
upstream raw materials:

cyanocobalamin

trimethyloxosulfonium bromide

Downstream raw materials:

[Co(I)cobalamin]

aquo[Co(III)cobalamin]

Refernces Edit
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