Benzaldehyde,2,3,6-trihydroxy-4-methyl-

Base Information

• Chemical Name: Benzaldehyde,2,3,6-trihydroxy-4-methyl-
• CAS No.: 15918-52-2
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.149
• Mol file: 15918-52-2.mol

Synonyms:p-Tolualdehyde,2,3,6-trihydroxy- (8CI); Thamnol

Chemical Property of Benzaldehyde,2,3,6-trihydroxy-4-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzaldehyde,2,3,6-trihydroxy-4-methyl-

There total 12 articles about Benzaldehyde,2,3,6-trihydroxy-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.5%

diisopropoxy-3,6-methoxy-2-methyl-4-benzaldehyde (118975-31-8) → trihydroxy-2,3,6-methyl-4-benzaldehyde (15918-52-2)

Guidance literature:

With boron tribromide; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1002/hlca.19880710424

Reference yield:

hydroxy-3-dimethoxy-4,6-methyl-2-benzoate de methyle (55366-04-6) → trihydroxy-2,3,6-methyl-4-benzaldehyde (15918-52-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / BCl₃ / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) CF₃COOH; 2.) H₂O / 1.) 16 h, 95 deg C; 2.) 5 h, 60 deg C

3: 96 percent / K₂CO₃ / dimethylformamide / 14 h / 40 °C

4: 60 percent / 10percent NaOH / dimethylsulfoxide / 7 h / 60 °C

5: 86 percent / 2,2'-bipyridine, Cu₂O / bis-(2-methoxy-ethyl) ether / 7 h / Heating

6: 13.5 percent / BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

With copper(I) oxide; [2,2]bipyridinyl; sodium hydroxide; water; boron trichloride; boron tribromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; diethylene glycol dimethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19880710424

Reference yield:

dihydroxy-3,6-methoxy-4-methyl-2-benzoate de methyle (91062-17-8) → trihydroxy-2,3,6-methyl-4-benzaldehyde (15918-52-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) CF₃COOH; 2.) H₂O / 1.) 16 h, 95 deg C; 2.) 5 h, 60 deg C

2: 96 percent / K₂CO₃ / dimethylformamide / 14 h / 40 °C

3: 60 percent / 10percent NaOH / dimethylsulfoxide / 7 h / 60 °C

4: 86 percent / 2,2'-bipyridine, Cu₂O / bis-(2-methoxy-ethyl) ether / 7 h / Heating

5: 13.5 percent / BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

With copper(I) oxide; [2,2]bipyridinyl; sodium hydroxide; water; boron tribromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; diethylene glycol dimethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19880710424

upstream raw materials:

formic acid

thamnolic acid

nonanoic acid

diisopropoxy-3,6-methoxy-2-methyl-4-benzaldehyde

Downstream raw materials:

2,5-dimethyl-1,3,4-trihydroxybenzene

acide decarboxythamnolique

(benzyloxycarbonyl)-3-hydroxy-2-methoxy-4-methyl-6-benzoate de formyl-3-dihydroxy-2,4-methyl-6-phenyl

Refernces