satavaptan

Base Information

Chemical Name:satavaptan
CAS No.:185913-78-4
Molecular Formula:C₃₃H₄₅N₃O₈S
Molecular Weight:643.802
Hs Code.:
Mol file:185913-78-4.mol

Synonyms:Benzamide,N-(1,1-dimethylethyl)-4-[[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro[cyclohexane-1,3'-[3H]indol]-1'(2'H)-yl]sulfonyl]-3-methoxy-,cis-; SR 121463; Satavaptan

Suppliers and Price of satavaptan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-(TERT-BUTYL)-4-([(1S,4S)-5'-ETHOXY-4-(2-MORPHOLIN-4-YLETHOXY)-2'-OXOSPIRO[CYCLOHEXANE-1,3'-INDOL]-1'(2'H)-YL]SULFONYL)-3-METHOXYBENZAMIDE 95.00%
5MG
$ 499.08

Total 36 raw suppliers

Chemical Property of satavaptan

Chemical Property:

Boiling Point:°Cat760mmHg
PKA:14.04±0.46(Predicted)
Flash Point:°C
PSA：135.58000
Density:1.31g/cm³
LogP:5.54540

Purity/Quality:

99% ^*data from raw suppliers

N-(TERT-BUTYL)-4-([(1S,4S)-5'-ETHOXY-4-(2-MORPHOLIN-4-YLETHOXY)-2'-OXOSPIRO[CYCLOHEXANE-1,3'-INDOL]-1'(2'H)-YL]SULFONYL)-3-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of satavaptan

There total 33 articles about satavaptan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72753-31-2
N-benzyl-N-(4-ethoxyphenyl)amine

: 185913-78-4
1'-[2-methoxy-4-(tert-butylaminocarboxamido)benzenesulfonyl]-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran / 5.5 h / Heating

1.2: 93 percent / MeSO₂N₃; Et₃N / acetonitrile / 12 h

2.1: 84 percent / KOH / acetonitrile; H₂O / 12 h / 20 °C

3.1: 88 percent / Rh₂(OAc)4 / CH₂Cl₂ / 12 h / 20 °C

4.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C

4.2: 90 percent / 1,2-dimethoxy-ethane / 16 h / 20 °C

5.1: 90 percent / PPTS / H₂O; acetone / 20 h / Heating

6.1: NaBH₄ / ethanol / 0 - 20 °C

7.1: NaH / toluene / 1.5 h / 100 °C

7.2: 80 percent / toluene / 14 h / Heating

8.1: 90 percent / Li; NH₃ / -78 °C

9.1: t-BuOK / tetrahydrofuran / -78 - 20 °C

9.2: tetrahydrofuran / -78 - 20 °C

With potassium hydroxide; sodium tetrahydroborate; potassium tert-butylate; ammonia; pyridinium p-toluenesulfonate; lithium; sodium hydride; dirhodium tetraacetate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jo0004658

Reference yield:

: 15484-91-0
N-benzylidene-4-ethoxyaniline

: 185913-78-4
1'-[2-methoxy-4-(tert-butylaminocarboxamido)benzenesulfonyl]-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: 23.31 g / NaBH₄ / methanol / 2 h / 20 °C

2.1: tetrahydrofuran / 5.5 h / Heating

2.2: 93 percent / MeSO₂N₃; Et₃N / acetonitrile / 12 h

3.1: 84 percent / KOH / acetonitrile; H₂O / 12 h / 20 °C

4.1: 88 percent / Rh₂(OAc)4 / CH₂Cl₂ / 12 h / 20 °C

5.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C

5.2: 90 percent / 1,2-dimethoxy-ethane / 16 h / 20 °C

6.1: 90 percent / PPTS / H₂O; acetone / 20 h / Heating

7.1: NaBH₄ / ethanol / 0 - 20 °C

8.1: NaH / toluene / 1.5 h / 100 °C

8.2: 80 percent / toluene / 14 h / Heating

9.1: 90 percent / Li; NH₃ / -78 °C

10.1: t-BuOK / tetrahydrofuran / -78 - 20 °C

10.2: tetrahydrofuran / -78 - 20 °C

With potassium hydroxide; sodium tetrahydroborate; potassium tert-butylate; ammonia; pyridinium p-toluenesulfonate; lithium; sodium hydride; dirhodium tetraacetate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jo0004658

Reference yield:

: 156-43-4
4-Ethoxyaniline

: 185913-78-4
1'-[2-methoxy-4-(tert-butylaminocarboxamido)benzenesulfonyl]-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: methanol / 0.03 h / Heating

2.1: 23.31 g / NaBH₄ / methanol / 2 h / 20 °C

3.1: tetrahydrofuran / 5.5 h / Heating

3.2: 93 percent / MeSO₂N₃; Et₃N / acetonitrile / 12 h

4.1: 84 percent / KOH / acetonitrile; H₂O / 12 h / 20 °C

5.1: 88 percent / Rh₂(OAc)4 / CH₂Cl₂ / 12 h / 20 °C

6.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C

6.2: 90 percent / 1,2-dimethoxy-ethane / 16 h / 20 °C

7.1: 90 percent / PPTS / H₂O; acetone / 20 h / Heating

8.1: NaBH₄ / ethanol / 0 - 20 °C

9.1: NaH / toluene / 1.5 h / 100 °C

9.2: 80 percent / toluene / 14 h / Heating

10.1: 90 percent / Li; NH₃ / -78 °C

11.1: t-BuOK / tetrahydrofuran / -78 - 20 °C

11.2: tetrahydrofuran / -78 - 20 °C

With potassium hydroxide; sodium tetrahydroborate; potassium tert-butylate; ammonia; pyridinium p-toluenesulfonate; lithium; sodium hydride; dirhodium tetraacetate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jo0004658