72753-31-2

Basic information

• Product Name: BENZYL-(4-ETHOXY-PHENYL)-AMINE
• Synonyms: BENZYL-(4-ETHOXY-PHENYL)-AMINE;Benzenemethanamine,N-(4-ethoxyphenyl)-;Benzyl-(4-Ethoxy-Phenyl)-Amine(WXC02964)
• CAS NO: 72753-31-2
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.30158
• Mol File: 72753-31-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZYL-(4-ETHOXY-PHENYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL-(4-ETHOXY-PHENYL)-AMINE(72753-31-2)
• EPA Substance Registry System: BENZYL-(4-ETHOXY-PHENYL)-AMINE(72753-31-2)

Safety Data

• Hazardous Substances Data: 72753-31-2(Hazardous Substances Data)

Usage

Description

BENZYL-(4-ETHOXY-PHENYL)-AMINE, with the molecular formula C15H17NO, is a chemical compound belonging to the amine class. It features a nitrogen atom bonded to carbon atoms and is characterized by the presence of a benzene ring, an ethoxy group attached to a phenyl ring, and a benzyl group connected to the amine nitrogen atom. This structural composition positions it as a versatile building block in the synthesis of pharmaceuticals and organic compounds, with potential applications in medicinal chemistry, drug discovery, and the production of dyes, polymers, and other industrial products.

Uses

Used in Pharmaceutical and Organic Compound Synthesis:
BENZYL-(4-ETHOXY-PHENYL)-AMINE is used as a building block for the synthesis of various pharmaceuticals and organic compounds, leveraging its unique structural features and functional groups to create a wide range of molecules with potential therapeutic and industrial applications.
Used in Medicinal Chemistry and Drug Discovery:
In the field of medicinal chemistry, BENZYL-(4-ETHOXY-PHENYL)-AMINE is utilized as a key component in the development of new drugs, contributing to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Dye Production:
BENZYL-(4-ETHOXY-PHENYL)-AMINE is used as a starting material or intermediate in the production of dyes, taking advantage of its chemical properties to create a variety of colorants for different applications.
Used in Polymer Production:
This chemical compound is also employed in the synthesis of polymers, where its structural elements can be incorporated into polymer chains to impart specific properties or functions to the final polymer product.
Used in Other Industrial Applications:
Beyond the fields of pharmaceuticals, dyes, and polymers, BENZYL-(4-ETHOXY-PHENYL)-AMINE finds use in various other industrial applications, capitalizing on its chemical reactivity and structural attributes to serve diverse needs in the chemical industry.

Upstream product

• 538-51-2 benzylidene phenylamine 
• 156-43-4 4-Ethoxyaniline 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 
• 100-44-7 benzyl chloride 
• 15484-91-0 N-benzylidene-4-ethoxyaniline 

Downstream Products

• 1422969-32-1 N¹,N⁴-dibenzyl-N¹,N⁴-bis(4-ethoxyphenyl)fumaramide 
• 185913-78-4 1-[4-(N-tert-butyl-carbamoyl)-2-methoxybenzene sulphonyl]-5-ethoxy-3-spiro-[4-(2-morpholinoethoxy)cyclohexane]indol-2-one; equatorial isomer 
• 185913-78-4 1'-[2-methoxy-4-(tert-butylaminocarboxamido)benzenesulfonyl]-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-69-3 1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-71-7 1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-66-0 1'-benzyl-5'-ethoxyspiro[cyclohexane-1,3'-indoline]-4,2'-dione cyclic 4-ethylene ketal 
• 346577-68-2 1'-benzyl-5'-ethoxy-4-hydroxyspiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-67-1 1′-benzyl-5′-ethoxyspiro[cyclohexane-1,3′-indoline]-2′,4-dione 
• 948551-98-2 1'-benzyl-5'-ethoxy-4-hydroxyspiro[cyclohexane-1,3'-indolin]-2'-one 
• 346577-65-9 1-benzyl-5-ethoxy-2-indolinone 
• 346577-64-8 N-benzyl-N-(4-ethoxyphenyl)diazoacetamide 
• 346577-70-6 N-benzyl-2-diazo-N-(4-ethoxy-phenyl)-malonamic acid methyl ester 
• 346577-63-7 N-benzyl-N-(4-ethoxyphenyl)-2-diazo-3-oxobutanamide 
• 102449-03-6 6-ethoxy-9-benzyl-1,2,3,4-tetrahydro-carbazole 

Relevant articles and documents

Tungsten-Catalyzed Direct N-Alkylation of Anilines with Alcohols

The implementation of non-noble metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as a straightforward and sustainable synthetic method, has attracted considerable attention in the development of non-noble metal catalysts. Herein, we report a tungsten-catalyzed N-alkylation reaction of anilines with primary alcohols via BH/HA. This phosphine-free W(phen)(CO)4 (phen=1,10-phenthroline) system was demonstrated as a practical and easily accessible in-situ catalysis for a broad range of amines and alcohols (up to 49 examples, including 16 previously undisclosed products). Notably, this tungsten system can tolerate numerous functional groups, especially the challenging substrates with sterically hindered substituents, or heteroatoms. Mechanistic insights based on experimental and computational studies are also provided.

Scalable synthesis of secondary and tertiary amines by heterogeneous Pt-Sn/γ-Al2O3catalyzed N-alkylation of amines with alcohols

Synthesis of secondary and tertiary amines has been efficiently realized from the N-alkylation of amines with alcohols by means of heterogeneous bimetallic Pt-Sn/γ-Al2O3catalyst (0.5?wt % Pt, molar ratio Pt:Sn?=?1:3) through a borrowing hydrogen strategy. The Pt-Sn/γ-Al2O3catalyst has exhibited very high catalytic activity towards a wide range of amines and alcohols, and can be conveniently recycled without Pt metal leaching. The present protocol was applied for the synthesis of N-phenylbenzylamine in 96% isolated yield from aniline and benzyl alcohol on a 2.1?kg scale of the substrates, demonstrating its potential applicability for higher-order amine synthesis.

Nano-sized NiLa2O4 spinel-NaBH4-mediated reduction of imines to secondary amines

Nano-sized NiLa2O4 spinel was produced by thermal decomposition of Ni-La compounds via a sol-gel method. The well-crystallized spinel structure was formed after calcination at 750 °C. The physicochemical properties of the spinel were investigated using differential thermal analysis, X-ray diffraction, transmission electron microscopy, scanning electron microscopy, and particle size distribution analysis. The results show that the nanoparticles have regular shapes with well-defined crystal faces and consist of uniform quasi-spherical crystallites of average size 40 nm. The refined unit cell parameters are a = 3.861205 ? and c = 12.6793 ?. This new nano-sized NiLa2O4 spinel is an efficient heterogeneous catalyst for the selective conversion of imines to the corresponding secondary amines in the presence of NaBH4 as a reducing agent, in good to excellent yields. All the reactions were completely chemoselective at room temperature and had relatively short reaction times. Secondary amines with different aryl groups, including those bearing electron-withdrawing or electron-donating groups, were obtained under the optimum reaction conditions. The catalyst was readily recovered and was recycled four times with no significant loss of catalytic activity.