Nicaraven

Base Information

Chemical Name:Nicaraven
CAS No.:79455-30-4
Molecular Formula:C₁₅H₁₆N₄O₂
Molecular Weight:284.318
Hs Code.:
UNII:UD8PEV6JBD,K13EV3J70Q,457KF8A3QQ
DSSTox Substance ID:DTXSID6046189
Nikkaji Number:J239.613K
NCI Thesaurus Code:C76580
Metabolomics Workbench ID:149759
ChEMBL ID:CHEMBL1705525
Mol file:79455-30-4.mol

Synonyms:1,2-bis(nicotinamido)propane;Antevas;N,N'-propylenebis(nicotinamide);nicaraven

Suppliers and Price of Nicaraven

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Nicaraven 95%
1 g
$ 1500.00

DC Chemicals
Nicaraven 95%
250 mg
$ 825.00

DC Chemicals
Nicaraven 95%
100 mg
$ 420.00

Crysdot
Nicaraven 97%
100mg
$ 149.00

Cayman Chemical
Nicaraven ≥98%
10mg
$ 50.00

Cayman Chemical
Nicaraven ≥98%
5mg
$ 28.00

Cayman Chemical
Nicaraven ≥98%
25mg
$ 102.00

Biosynth Carbosynth
Nicaraven
10 mg
$ 62.50

Biosynth Carbosynth
Nicaraven
50 mg
$ 81.00

Arctom
Nicaraven
10mg
$ 26.00

Total 45 raw suppliers

Chemical Property of Nicaraven

Chemical Property:

Vapor Pressure:4.53E-16mmHg at 25°C
Melting Point:156-157°
Refractive Index:1.584
Boiling Point:635.9 °C at 760 mmHg
Flash Point:338.4 °C
PSA：83.98000
Density:1.213 g/cm³
LogP:1.80670
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:284.12732577
Heavy Atom Count:21
Complexity:362

Purity/Quality:

99%, ^*data from raw suppliers

Nicaraven 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CNC(=O)C1=CN=CC=C1)NC(=O)C2=CN=CC=C2
Description Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro. Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver. Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2''-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury.

Technology Process of Nicaraven

There total 4 articles about Nicaraven which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: