Technology Process of Silane,
[[(1R,3S,4S,5Z)-4-(bromomethyl)-5-[bromo(trimethylsilyl)methylene]-1,3
-cyclohexanediyl]bis(oxy)]bis[(1,1-dimethylethyl)dimethyl-
There total 8 articles about Silane,
[[(1R,3S,4S,5Z)-4-(bromomethyl)-5-[bromo(trimethylsilyl)methylene]-1,3
-cyclohexanediyl]bis(oxy)]bis[(1,1-dimethylethyl)dimethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole;
In
N,N-dimethyl-formamide;
DOI:10.1021/ol0274007
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisopropyl (L)-(+)-tartrate; Ti(O-i-Pr)4; t-BuOOH / CH2Cl2 / 24 h / -20 °C
2.1: Et3N / CH2Cl2 / 1 h / 0 °C
3.1: NaI; NaHCO3 / acetone / 20 h / 20 °C
4.1: 21.7 g / Zn; AcOH / methanol / 1 h / sonication
5.1: i-PrMgCl; Ti(O-i-Pr)4 / diethyl ether / -78 - -50 °C
5.2: 51 percent / NBS / diethyl ether; tetrahydrofuran / -78 - 20 °C
6.1: 96 percent / imidazole / dimethylformamide / 12 h / 20 °C
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; diisopropyl (L)-tartrate; isopropylmagnesium chloride; sodium hydrogencarbonate; acetic acid; triethylamine; sodium iodide; zinc;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
1.1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo0353435
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: BF3*Et2O / tetrahydrofuran; hexane / -78 - 20 °C
1.3: 82 percent / hydrochloric acid / tetrahydrofuran / 1 h / 20 °C
2.1: 96 percent / porcine pancreatic lipase / 72 h / 20 °C
3.1: imidazole / dimethylformamide / 12 h / 20 °C
4.1: 27.8 g / Red-Al / diethyl ether; toluene / 1 h / 0 °C
5.1: diisopropyl (L)-(+)-tartrate; Ti(O-i-Pr)4; t-BuOOH / CH2Cl2 / 24 h / -20 °C
6.1: Et3N / CH2Cl2 / 1 h / 0 °C
7.1: NaI; NaHCO3 / acetone / 20 h / 20 °C
8.1: 21.7 g / Zn; AcOH / methanol / 1 h / sonication
9.1: i-PrMgCl; Ti(O-i-Pr)4 / diethyl ether / -78 - -50 °C
9.2: 51 percent / NBS / diethyl ether; tetrahydrofuran / -78 - 20 °C
10.1: 96 percent / imidazole / dimethylformamide / 12 h / 20 °C
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; porcine pancreatic lipase; diisopropyl (L)-tartrate; isopropylmagnesium chloride; sodium hydrogencarbonate; acetic acid; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide; zinc;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
5.1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo0353435
