3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid

Base Information

Chemical Name:3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid
CAS No.:502607-25-2
Molecular Formula:C10H9F3O4
Molecular Weight:250.17100
Hs Code.:2918990090
European Community (EC) Number:674-755-5
DSSTox Substance ID:DTXSID20476682

Synonyms:3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid;502607-25-2;3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propanoic acid;DTXSID20476682;MFCD07780100;AKOS023105482;3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionicacid

Suppliers and Price of 3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionicacid 95+%
5g
$ 715.00

American Custom Chemicals Corporation
3,3,3-TRIFLUORO-2-HYDROXY-2-(4-METHOXYPHENYL)PROPIONIC ACID 95.00%
5MG
$ 499.68

Total 5 raw suppliers

Chemical Property of 3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid

Chemical Property:

Vapor Pressure:2.13E-06mmHg at 25°C
Boiling Point:378.4oC at 760 mmHg
PKA:1.91±0.25(Predicted)
Flash Point:182.6oC
PSA：66.76000
Density:1.453g/cm3
LogP:1.52970
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:250.04529325
Heavy Atom Count:17
Complexity:284

Purity/Quality:

98% ^*data from raw suppliers

3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(C(=O)O)(C(F)(F)F)O

Technology Process of 3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid

There total 2 articles about 3,3,3-Trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 502607-05-8
3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid ethyl ester

: 502607-25-2
3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propanoic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃;
DOI:10.1016/S0040-4020(02)00947-X

Reference yield:

: 699-19-4
4-methoxyphenylmagnesium chloride

: 502607-25-2
3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / tetrahydrofuran / 1 h / -78 °C

2: 100 percent / KOH / ethanol / 20 °C

With potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/S0040-4020(02)00947-X

Reference yield: 85.0%

: 502607-25-2
3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propanoic acid

: 711-38-6
4'-methoxy-2,2,2-trifluoroacetophenone

Guidance literature:: With Co(III) ortho-phenylene-bis(N'-methyloxamidate); oxygen; pivalaldehyde; In dichloromethane;
DOI:10.1016/S0040-4020(02)00947-X