502607-05-8Relevant academic research and scientific papers
Superacid catalyzed hydroxyalkylation of aromatics with ethyl trifluoropyruvate: A new synthetic route to Mosher's acid analogs
Prakash, G. K. Surya,Yan, Ping,T?r?k, Béla,Olah, George A.
, p. 527 - 531 (2007/10/03)
A new superacid catalyzed Friedel-Crafts hydroxyalkylation of aromatics with ethyl trifluoropyruvate is described. The trifluoromethanesulfonic acid or gallium(III) trifluoromethane-sulfonate catalyzed reactions give α-hydroxy α-trifluoromethyl phenyl acetic acid ethyl ester and its derivatives (analogs of Mosher's acid) in good yields for both highly activated heteroaromatics and substituted benzenes.
Catalytic aerobic oxidative decarboxylation of α-trifluoromethyl-α-hydroxy acids to trifluoromethyl ketones
Blay, Gonzalo,Fernández, Isabel,Marco-Aleixandre, Alicia,Monje, Belén,Pedro, José R,Ruiz, Rafael
, p. 8565 - 8571 (2007/10/03)
The oxidative decarboxylation of α-trifluoromethyl-α-hydroxy acids to trifluoromethyl ketones is carried out under mild catalytic aerobic conditions using a cobalt(III) complex in the presence of pivalaldehyde.
