502607-05-8

Basic information

• Product Name: 3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid ethyl ester
• Synonyms: 3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid ethyl ester
• CAS NO: 502607-05-8
• Molecular Weight: 278.228
• Mol File: 502607-05-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid ethyl ester(502607-05-8)
• EPA Substance Registry System: 3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid ethyl ester(502607-05-8)

Safety Data

• Hazardous Substances Data: 502607-05-8(Hazardous Substances Data)

Upstream product

• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 699-19-4 4-methoxyphenylmagnesium chloride 
• 100-66-3 methoxybenzene 

Downstream Products

• 711-38-6 4'-methoxy-2,2,2-trifluoroacetophenone 
• 502607-25-2 3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propanoic acid 

Relevant articles and documents

Superacid catalyzed hydroxyalkylation of aromatics with ethyl trifluoropyruvate: A new synthetic route to Mosher's acid analogs

A new superacid catalyzed Friedel-Crafts hydroxyalkylation of aromatics with ethyl trifluoropyruvate is described. The trifluoromethanesulfonic acid or gallium(III) trifluoromethane-sulfonate catalyzed reactions give α-hydroxy α-trifluoromethyl phenyl acetic acid ethyl ester and its derivatives (analogs of Mosher's acid) in good yields for both highly activated heteroaromatics and substituted benzenes.