699-19-4

Upstream product

• 623-12-1 4-chloromethoxybenzene 
• 696-62-8 para-iodoanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 70529-50-9 methyl 2-acetylamino-3-(4-methoxyphenyl)propanoate 
• 38204-31-8 2-((4-methoxyphenylcarbonothioyl)thio)acetic acid 
• 67103-60-0 (4-methoxy-phenyl)-phosphonous acid diethyl ester 
• 104-46-1 anethole 
• 877-99-6 1-methoxy-4-(2-methyl-1-propenyl)benzene 
• 3893-10-5 (1E,3E,5E)-1-(p-methoxyphenyl)-6-phenyl-1,3,5-hexatriene 
• 709-12-6 1-(p-methoxyphenyl)-1-cyclopentene 
• 612-75-9 3,3'-dimethyl-biphenyl 
• 17171-17-4 4'-methoxy-3-methylbiphenyl 
• 502607-05-8 3,3,3-trifluoro-2-hydroxy-2-(4-methoxyphenyl)propionic acid ethyl ester 
• 149192-03-0 1,1-Bis(4-methoxyphenyl)heptene 

Relevant academic research and scientific papers

Regioselective 1,4-conjugate addition of grignard reagents to nitrodienes in the presence of catalytic amounts of Zn(II) salts

Grignard reagents undergo facile regioselective 1,4-conjugate addition to nitrodienes in the presence of catalytic amounts of Zn(II) salts with excellent yields. A wide range of ligands such as alkyl, aryl, heteroaryl, allyl, vinyl, 1-alkynyl, and alkoxy ligands were transferred, while a thiolate ligand afforded 1,6-regioselectivity. The reactions were successfully carried out on δ-alkyl- or aryl-substituted α,β,γ,δ-diunsaturated nitrodiene substrates. Regioselectivity is minimally influenced by temperature or choice of solvent.

Cobalt-catalyzed addition of arylzinc reagents to alkynes to form ortho-alkenylarylzinc species through 1,4-cobalt migration

Migratory carbometalation: A cobalt-Xantphos complex catalyzes the addition of an arylzinc reagent to an unactivated internal alkyne; the reaction most likely involves insertion of the alkyne into an arylcobalt species and vinyl-to-aryl 1,4-cobalt migration, followed by transmetalation with the arylzinc reagent. Interception of the resulting ortho-alkenylarylzinc species with electrophiles allows access to 1-alkenyl arenes functionalized in the 2-position. Copyright

Arylzinc species by microwave assisted Grignard formation-transmetallation sequence: Application in the Negishi coupling

Arylmagnesium species can be efficiently generated from magnesium turnings and aryl chlorides or aryl bromides under dielectric heating conditions. Subsequent microwave assisted transmetallation using ZnCl2-TMEDA afforded the corresponding arylzinc reagents. A sequential microwave assisted arylmagnesium formation-transmetallation-Negishi coupling protocol suitable for automated multiple parallel synthesis has been developed.