L-Leucine, N-[(2S)-4-methyl-1-oxo-2-[[[[(1-oxo-3-phenylpropyl)amino]methyl]diphen ylsilyl]methyl]pentyl]-, 1,1-dimethylethyl ester

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Chemical Name:L-Leucine, N-[(2S)-4-methyl-1-oxo-2-[[[[(1-oxo-3-phenylpropyl)amino]methyl]diphen ylsilyl]methyl]pentyl]-, 1,1-dimethylethyl ester
CAS No.:503066-41-9
Molecular Formula:C39H54N2O4Si
Molecular Weight:642.954
Hs Code.:

Synonyms:

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Chemical Property of L-Leucine, N-[(2S)-4-methyl-1-oxo-2-[[[[(1-oxo-3-phenylpropyl)amino]methyl]diphen ylsilyl]methyl]pentyl]-, 1,1-dimethylethyl ester

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Technology Process of L-Leucine, N-[(2S)-4-methyl-1-oxo-2-[[[[(1-oxo-3-phenylpropyl)amino]methyl]diphen ylsilyl]methyl]pentyl]-, 1,1-dimethylethyl ester

There total 15 articles about L-Leucine, N-[(2S)-4-methyl-1-oxo-2-[[[[(1-oxo-3-phenylpropyl)amino]methyl]diphen ylsilyl]methyl]pentyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 645-45-4
hydrocinnamic acid chloride

: 503066-40-8
(S)-2-[(S)-2-[[(aminomethyl)diphenylsilanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid tert-butyl ester

: 503066-41-9
(S)-2-[(S)-2-[[diphenyl[(3-phenylpropionylamino)methyl]silanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid tert-butyl ester

Guidance literature:: DOI:10.1016/S0960-894X(02)00804-1

Reference yield:

: 503066-37-3
(S)-[2-(benzyloxymethyl)-4-methylpentyl](chloromethyl)diphenylsilane

: 503066-41-9
(S)-2-[(S)-2-[[diphenyl[(3-phenylpropionylamino)methyl]silanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / dimethylformamide / 90 - 100 °C

2: 74 percent / boron tribromide / CH₂Cl₂ / 2 h / -78 °C

3: N-methylmorpholine N-oxide / tetrapropylammonium perruthenate / CH₂Cl₂ / 2 h / 20 °C

4: 90 percent / NaClO₂; sodium dihydrogen phosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

5: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; diisopropylethylamine / CH₂Cl₂ / 25 h / 0 - 20 °C

6: 91 percent / hydrazine / ethanol / 2 h / Heating

7: 84 percent / NaHCO₃ / diethyl ether; H₂O / 1.5 h / 0 °C

With sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene; boron tribromide; sodium hydrogencarbonate; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; tetrapropylammonium perruthennate; In diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 4: Pinnick oxidation;
DOI:10.1021/jo049929i

Reference yield:

: 503066-36-2
(chloromethyl)fluorodiphenylsilane

: 503066-41-9
(S)-2-[(S)-2-[[diphenyl[(3-phenylpropionylamino)methyl]silanyl]methyl]-4-methylpentanoylamino]-4-methylpentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: tert-butyllithium / diethyl ether; pentane / 2 h / -78 - 20 °C

1.2: 74 percent / diethyl ether; pentane / 41 h / 0 - 20 °C

2.1: 73 percent / dimethylformamide / 90 - 100 °C

3.1: 74 percent / boron tribromide / CH₂Cl₂ / 2 h / -78 °C

4.1: N-methylmorpholine N-oxide / tetrapropylammonium perruthenate / CH₂Cl₂ / 2 h / 20 °C

5.1: 90 percent / NaClO₂; sodium dihydrogen phosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

6.1: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt; diisopropylethylamine / CH₂Cl₂ / 25 h / 0 - 20 °C

7.1: 91 percent / hydrazine / ethanol / 2 h / Heating

8.1: 84 percent / NaHCO₃ / diethyl ether; H₂O / 1.5 h / 0 °C

With sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene; tert.-butyl lithium; boron tribromide; sodium hydrogencarbonate; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; tetrapropylammonium perruthennate; In diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; pentane; 5.1: Pinnick oxidation;
DOI:10.1021/jo049929i