Benzylidenehydrazine

Base Information

• Chemical Name: Benzylidenehydrazine
• CAS No.: 5281-18-5
• Molecular Formula: C7H8 N2
• Molecular Weight: 120.154
• Hs Code.: 2928000090
• Nikkaji Number: J543.856J
• Mol file: 5281-18-5.mol

Synonyms:Benezalhydrazone;benzylidenehydrazine;Benzylidene hydrazine;5281-18-5;Benzaldehyde, hydrazone;SCHEMBL13832589;NSC 32341;LS-25058;D81797;(6R,7R)-7-amimo-8-oxo-3-(1-propenyl)-5-thia-1-azabicylo[4.2.0]oct-2-ene-2-carboxylicacid

Chemical Property of Benzylidenehydrazine

Chemical Property:

• Vapor Pressure: 0.0514mmHg at 25°C
• Melting Point: 16°C
• Refractive Index: 1.5290 (estimate)
• Boiling Point: 235°Cat760mmHg
• PKA: 2.22±0.70(Predicted)
• Flash Point: 95.9°C
• PSA: 38.38000
• Density: 1.01g/cm³
• LogP: 1.67950
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 120.068748264
• Heavy Atom Count: 9
• Complexity: 93.1

Purity/Quality:

97% ^*data from raw suppliers

Hydrazonebenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=NN
• Isomeric SMILES: C1=CC=C(C=C1)/C=N\N
• Uses: Hydrazone benzaldehyde is a useful synthetic compound and can be used as an analyte in some biological studies.

Technology Process of Benzylidenehydrazine

There total 30 articles about Benzylidenehydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzaldehyde (100-52-7) → benzaldehyde, hydrazone (5281-18-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 100h; Inert atmosphere;

Reference yield: 98.0%

1-phenyl-3-methoxy-2-aza-1-butene (70509-12-5) → benzaldehyde, hydrazone (5281-18-5)

Guidance literature:

With hydrazine hydrate;

Reference yield: 94.0%

benzaldehyde N,N-dimethylhydrazone (1075-70-3) → benzaldehyde, hydrazone (5281-18-5)

Guidance literature:

With hydrazine; In ethanol; for 3h; Heating;

upstream raw materials:

(Z)-benzaldehyde oxime

ethanol

benzaldehyde

benzaldehyde benzylidenehydrazone

Downstream raw materials:

chloro-acetic acid benzylidenehydrazide

benzoylhydrazone of benzaldehyde

benzylidene-(3-nitro-benzylidene)-hydrazine

benzylidene-[5-(4-methoxy-phenyl)-[1,2]dithiol-3-ylidene]-hydrazine

Refernces

1-Acylthiosemicarbazides, 1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic-anti-inflammatory and antimicrobial activities

10.1016/j.bmc.2007.06.006

In the research, 5-methyl-2-benzoxazolinone (referred to as compound 2) serves as a key starting material for the synthesis of various derivatives with potential analgesic, anti-inflammatory, and antimicrobial activities. It is synthesized by reacting 5-methyl-2-hydroxyaniline with urea, following a literature method. The research aims to synthesize and investigate the analgesic, anti-inflammatory, and antimicrobial properties of various derivatives of 5-methyl-2-benzoxazolinones. The study involves the synthesis of thiosemicarbazide derivatives, 1,2,4-triazoles, 1,3,4-thiadiazoles, and benzylidene hydrazines by reacting 2-(5-methyl-2-benzoxazolinone-3-yl)acetate with hydrazine hydrate and various isothiocyanates or aldehydes. The synthesized compounds were characterized using spectral and elemental analysis. The results showed that most compounds exhibited significant analgesic and anti-inflammatory activities, comparable to or higher than aspirin, with some compounds like 7a, 8c, and 8d showing strong analgesic effects in both acetic acid-induced writhing and hot plate tests. The compound 6d was particularly effective in anti-inflammatory tests. However, most compounds showed poor antibacterial activity but promising antifungal activity, with compounds 4, 5a, 6d, 8a, 8d, and 8e demonstrating moderate inhibitory effects against certain Candida species. The study concludes that these derivatives, especially those with thiadiazole moieties and benzylidene hydrazines, are promising candidates for developing new analgesic and anti-inflammatory drugs, though further research is needed to explore their mechanisms and potential side effects.

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