[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-

Base Information

Chemical Name:[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-
CAS No.:503860-57-9
Molecular Formula:C19H18FN5O2
Molecular Weight:367.383
Hs Code.:
Mol file:503860-57-9.mol

Synonyms:2-[(2S)-2-(2-(4-fluorophenyl)morpholin-4-yl)]-1-methyl-1H-[4,4']bipyrimidinyl-6-one;

Suppliers and Price of [4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
SAR502250 99.90%
100mg
$ 5000.00

ChemScene
SAR502250 99.90%
50mg
$ 3200.00

ChemScene
SAR502250 99.90%
25mg
$ 1900.00

ChemScene
SAR502250 99.90%
10mg
$ 980.00

ChemScene
SAR502250 99.90%
5mg
$ 580.00

Total 2 raw suppliers

Chemical Property of [4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-

Chemical Property:

Boiling Point:547.2±60.0 °C(Predicted)
PSA：73.14000
Density:1.38±0.1 g/cm3(Predicted)
LogP:2.01930

Purity/Quality:

97% ^*data from raw suppliers

SAR502250 99.90% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-

There total 12 articles about [4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 503860-54-6
2-chloro-3-methyl-6-(pyrimidin-4-yl)-pyrimidine-4-one

: 790655-16-2
(2S)-2-(4-fluorophenyl)morpholine

: 503860-57-9
UDA-680

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 503860-54-6
2-chloro-3-methyl-6-(pyrimidin-4-yl)-pyrimidine-4-one

: 503860-58-0
(2S)-2-(4-fluorophenyl)morpholine hydrochloride

: 503860-57-9
UDA-680

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2013.09.020

Reference yield:

: 920796-73-2
(6S)-6-(4-fluorophenyl)-4-benzylmorpholine-3-one

: 503860-57-9
UDA-680

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran / 20 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 20 °C

2.2: Reflux

3.1: triethylamine / tetrahydrofuran / 20 °C

With lithium borohydride; chloro-trimethyl-silane; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2013.09.020