(6S)-4-benzyl-6-(4-fluorophenyl)morpholin-3-one

Base Information

Chemical Name:(6S)-4-benzyl-6-(4-fluorophenyl)morpholin-3-one
CAS No.:920796-73-2
Molecular Formula:C17H16FNO2
Molecular Weight:285.318
Hs Code.:
DSSTox Substance ID:DTXSID50580645

Synonyms:(6S)-4-benzyl-6-(4-fluorophenyl)morpholin-3-one;920796-73-2;SCHEMBL2292500;DTXSID50580645;CPUPVIAGLRJXFM-MRXNPFEDSA-N;(6S)-4-benzyl-6-(4-fluorophenyl) morpholin-3-one;(6S)-6-(4-fluorophenyl)-4-(benzyl)morpholin-3-one

Suppliers and Price of (6S)-4-benzyl-6-(4-fluorophenyl)morpholin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (6S)-4-benzyl-6-(4-fluorophenyl)morpholin-3-one

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:285.11650692
Heavy Atom Count:21
Complexity:349

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OCC(=O)N1CC2=CC=CC=C2)C3=CC=C(C=C3)F
Isomeric SMILES:C1[C@@H](OCC(=O)N1CC2=CC=CC=C2)C3=CC=C(C=C3)F

Technology Process of (6S)-4-benzyl-6-(4-fluorophenyl)morpholin-3-one

There total 8 articles about (6S)-4-benzyl-6-(4-fluorophenyl)morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 920797-21-3
N-benzyl-2-chloro-N-[(2S)-2-(4-fluorophenyl)-2-hydroxyethyl]acetamide

: 920796-73-2
(6S)-6-(4-fluorophenyl)-4-benzylmorpholine-3-one

Guidance literature:: With potassium tert-butylate; at 22 ℃; for 1.5h; Large scale;

Reference yield:

: (1S)-2-(benzylamino)-1-(4-fluorophenyl)ethanol

: 920796-73-2
(6S)-6-(4-fluorophenyl)-4-benzylmorpholine-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; dichloromethane / 0.67 h / 0 - 3 °C / Large scale

1.2: 2 h / 0 - 6 °C / Large scale

2.1: potassium tert-butylate / 1.5 h / 22 °C / Large scale

With potassium tert-butylate; sodium hydroxide; In dichloromethane; water;

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 920796-73-2
(6S)-6-(4-fluorophenyl)-4-benzylmorpholine-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; borane N,N-diethylaniline complex / toluene; tert-butyl methyl ether / 2.5 h / 40 °C / Inert atmosphere; Large scale

1.2: 0.5 h / 10 - 20 °C / Large scale

2.1: sodium hydroxide / water; tert-butyl methyl ether / 3 h / 20 - 22 °C / Large scale

3.1: 21 h / 20 - 80 °C / Inert atmosphere; Large scale

4.1: sodium hydroxide / water; dichloromethane / 0.67 h / 0 - 3 °C / Large scale

4.2: 2 h / 0 - 6 °C / Large scale

5.1: potassium tert-butylate / 1.5 h / 22 °C / Large scale

With borane N,N-diethylaniline complex; potassium tert-butylate; sodium hydroxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In dichloromethane; tert-butyl methyl ether; water; toluene;