(S)-4-Benzyl-2-(4-fluorophenyl)morpholine

Base Information

Chemical Name:(S)-4-Benzyl-2-(4-fluorophenyl)morpholine
CAS No.:920796-74-3
Molecular Formula:C17H18FNO
Molecular Weight:271.334
Hs Code.:
DSSTox Substance ID:DTXSID60475593
Wikidata:Q82306221

Synonyms:(S)-4-Benzyl-2-(4-fluorophenyl)morpholine;(2S)-4-benzyl-2-(4-fluorophenyl)morpholine;(2S)-2-(4-fluorophenyl)-4-(benzyl)morpholine;920796-74-3;SCHEMBL2298750;DTXSID60475593;UVNKZRUDJYONQQ-QGZVFWFLSA-N;MFCD28005214;(S)-2-(4-FLUOROPHENYL)MORPHOLINE HCL;S11135;(25)-2-(4-fluorophenyl)-4-(benzyl)morpholine

Suppliers and Price of (S)-4-Benzyl-2-(4-fluorophenyl)morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of (S)-4-Benzyl-2-(4-fluorophenyl)morpholine

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:271.137242360
Heavy Atom Count:20
Complexity:285

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC(CN1CC2=CC=CC=C2)C3=CC=C(C=C3)F
Isomeric SMILES:C1CO[C@H](CN1CC2=CC=CC=C2)C3=CC=C(C=C3)F

Technology Process of (S)-4-Benzyl-2-(4-fluorophenyl)morpholine

There total 9 articles about (S)-4-Benzyl-2-(4-fluorophenyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 920796-73-2
(6S)-6-(4-fluorophenyl)-4-benzylmorpholine-3-one

: 920796-74-3
(2S)-4-benzyl-2-(4-fluorophenyl)morpholine

Guidance literature:: (6S)-6-(4-fluorophenyl)-4-benzylmorpholine-3-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃; for 1.5h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

: 920797-21-3
N-benzyl-2-chloro-N-[(2S)-2-(4-fluorophenyl)-2-hydroxyethyl]acetamide

: 920796-74-3
(2S)-4-benzyl-2-(4-fluorophenyl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / 1.5 h / 22 °C / Large scale

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 70 °C / Inert atmosphere

2.2: 0.5 h / 0 °C

With lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran;

Reference yield:

: (1S)-2-(benzylamino)-1-(4-fluorophenyl)ethanol

: 920796-74-3
(2S)-4-benzyl-2-(4-fluorophenyl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; dichloromethane / 0.67 h / 0 - 3 °C / Large scale

1.2: 2 h / 0 - 6 °C / Large scale

2.1: potassium tert-butylate / 1.5 h / 22 °C / Large scale

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 70 °C / Inert atmosphere

3.2: 0.5 h / 0 °C

With lithium aluminium tetrahydride; potassium tert-butylate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;