2-Morpholin-4-YL-2-oxoethanol

Base Information

• Chemical Name: 2-Morpholin-4-YL-2-oxoethanol
• CAS No.: 51068-78-1
• Molecular Formula: C6H11NO3
• Molecular Weight: 145.158
• European Community (EC) Number: 824-948-7
• DSSTox Substance ID: DTXSID30424295
• Nikkaji Number: J2.493.444F
• Wikidata: Q82236813
• ChEMBL ID: CHEMBL447999
• Mol file: 51068-78-1.mol

Synonyms:51068-78-1;2-MORPHOLIN-4-YL-2-OXOETHANOL;2-hydroxy-1-(morpholin-4-yl)ethan-1-one;2-Hydroxy-1-morpholinoethanone;2-hydroxy-1-morpholin-4-ylethanone;2-(4-morpholinyl)-2-oxoethanol;2-HYDROXY-1-(MORPHOLIN-4-YL)ETHANONE;4-(Hydroxyacetyl)morpholine;2-Hydroxy-1-(4-morpholinyl)ethanone;4-glycolyl-morpholine;SCHEMBL424000;CHEMBL447999;AMY3665;DTXSID30424295;EX-A606;PHCSTEJVICOGEJ-UHFFFAOYSA-N;4-Morpholineethanol, .beta.-oxo-;2-hydroxy-1-morpholinoethan-1-one;BCA06878;BCP15284;MFCD08436413;2-hydroxy-1-morpholin-4-yl-ethanone;AKOS009590767;AB44986;2-HYDROXY-1-MORPHOLINO-ETHANONE;BS-13277;CS-0028591;FT-0700321;EN300-70344;W10210;A871384;AO-365/41652214;J-690311;Z431952730

Chemical Property of 2-Morpholin-4-YL-2-oxoethanol

Chemical Property:

• Storage Temp.: 2-8°C
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 145.07389321
• Heavy Atom Count: 10
• Complexity: 120

Purity/Quality:

97% ^*data from raw suppliers

2-hydroxy-1-(morpholin-4-yl)ethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1C(=O)CO

Technology Process of 2-Morpholin-4-YL-2-oxoethanol

There total 2 articles about 2-Morpholin-4-YL-2-oxoethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dimorpholinoethane-1,2-dione (6342-79-6) → 2-(morpholin-4-yl)ethanol (622-40-2) + 2-hydroxy-1-(morpholin-4-yl)ethan-1-one (51068-78-1) + ethylene glycol (107-21-1)

Guidance literature:

With hydrogen; Cu/Al₂O₃/SiO₂; In methanol; at 170 ℃; for 16.5h; under 41254.1 Torr; Autoclave;

Reference yield:

morpholinocarbamoylmethyl 2-[3-(trifluoromethyl)anilino]nicotinic ester (533925-45-0) → morpholine (110-91-8,99108-56-2) + 2-hydroxy-1-(morpholin-4-yl)ethan-1-one (51068-78-1) + Niflumic Acid (4394-00-7)

Guidance literature:

With potassium chloride; In phosphate buffer; acetonitrile; at 37 ℃; for 0.266667h; pH=7.4; Kinetics; Enzymatic reaction;

Reference yield: 75.0%

2-hydroxy-1-(morpholin-4-yl)ethan-1-one (51068-78-1) + 3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole (1446358-48-0) → C23H20F2N6O4

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 23 ℃; for 5h;

upstream raw materials:

morpholinocarbamoylmethyl 2-[3-(trifluoromethyl)anilino]nicotinic ester

1,2-dimorpholinoethane-1,2-dione

Downstream raw materials:

2-(4-chloro-phenoxy)-2-methyl-propionic acid 2-morpholin-4-yl-2-oxo-ethyl ester

4,4'-[Oxybis(1-oxoethan-2,1-diyl)]bis[morpholin]

(morpholin-4-yl)(3-phenylfuro[2,3-b]pyridin-2-yl)methanone