5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(4-nitrophen yl)-1-piperazinyl]-3-oxopropyl]phenyl ester

Base Information

Chemical Name:5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(4-nitrophen yl)-1-piperazinyl]-3-oxopropyl]phenyl ester
CAS No.:516473-18-0
Molecular Formula:C34H37N5O8S
Molecular Weight:675.762
Hs Code.:

5-Isoquinolinesulfonic acid,
4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(4-nitrophen
yl)-1-piperazinyl]-3-oxopropyl]phenyl ester

Synonyms:

Suppliers and Price of 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(4-nitrophen yl)-1-piperazinyl]-3-oxopropyl]phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(4-nitrophen yl)-1-piperazinyl]-3-oxopropyl]phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(4-nitrophen yl)-1-piperazinyl]-3-oxopropyl]phenyl ester

There total 3 articles about 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3-[4-(4-nitrophen yl)-1-piperazinyl]-3-oxopropyl]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 84468-15-5
5-isoquinolinesulfonyl chloride

: 516472-90-5
1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

: 516473-18-0
1-[(S)-O-5-isoquinolinesulfonyl-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

Guidance literature:: 1-[(S)-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine; With sodium hydride; In tetrahydrofuran; for 0.166667h;

5-isoquinolinesulfonyl chloride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm021049d

Reference yield:

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 516473-18-0
1-[(S)-O-5-isoquinolinesulfonyl-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / EDC; HOBt / dimethylformamide / 24 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: 79 percent / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

With sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm021049d

Reference yield:

: 82038-34-4
(S)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-hydroxyphenyl)propanoic acid

: 516473-18-0
1-[(S)-O-5-isoquinolinesulfonyl-N-tert-butyloxycarbonyl-N-methyltyrosyl]-4-(4-nitrophenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / EDC; HOBt / dimethylformamide / 24 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: 79 percent / tetrahydrofuran; CH₂Cl₂ / 18 h / 20 °C

With sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm021049d