Benzoic acid, 4-formyl-, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethoxy)carbon yl]amino]methyl]ethyl ester

Base Information

• Chemical Name: Benzoic acid, 4-formyl-, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethoxy)carbon yl]amino]methyl]ethyl ester
• CAS No.: 518335-42-7
• Molecular Formula: C21H30N2O7
• Molecular Weight: 422.478
• Mol file: 518335-42-7.mol

Synonyms:

Chemical Property of Benzoic acid, 4-formyl-, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethoxy)carbon yl]amino]methyl]ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-formyl-, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethoxy)carbon yl]amino]methyl]ethyl ester

There total 1 articles about Benzoic acid, 4-formyl-, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[[(1,1-dimethylethoxy)carbon yl]amino]methyl]ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-Carboxybenzaldehyde (619-66-9) + (3-tert-butoxycarbonylamino-2-hydroxy-propyl)-carbamic acid tert-butyl ester (98642-15-0) → 2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyl 4-formylbenzoate (518335-42-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(03)00466-6

Reference yield: 93.0%

2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyl 4-formylbenzoate (518335-42-7) → 4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid (503442-20-4)

Guidance literature:

With potassium permanganate; In pyridine; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(03)00466-6

Reference yield:

2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyl 4-formylbenzoate (518335-42-7) → C39H54N10O9*6C2HF3O2

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / KMnO₄ / pyridine / 0 - 20 °C

2: 83 percent / Et₃N; BOP / acetonitrile / 48 h / 20 °C

3: 100 percent / CH₂Cl₂ / 3 h / 20 °C

With potassium permanganate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In pyridine; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(03)00466-6

upstream raw materials:

4-Carboxybenzaldehyde

(3-tert-butoxycarbonylamino-2-hydroxy-propyl)-carbamic acid tert-butyl ester

Downstream raw materials:

4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid

C₆₉H₁₀₂N₁₀O₂₁