4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid

Base Information

• Chemical Name: 4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid
• CAS No.: 503442-20-4
• Molecular Formula: C₂₁H₃₀N₂O₈
• Molecular Weight: 438.478

Synonyms:4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid

Chemical Property of 4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid

Chemical Property:

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Technology Process of 4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid

There total 3 articles about 4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyl 4-formylbenzoate (518335-42-7) → 4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid (503442-20-4)

Guidance literature:

With potassium permanganate; In pyridine; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(03)00466-6

Reference yield:

4-Carboxybenzaldehyde (619-66-9) → 4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid (503442-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / DMAP; dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 20 °C

2: 93 percent / KMnO₄ / pyridine / 0 - 20 °C

With dmap; potassium permanganate; dicyclohexyl-carbodiimide; In pyridine; dichloromethane;

DOI:10.1016/S0040-4020(03)00466-6

Reference yield:

(3-tert-butoxycarbonylamino-2-hydroxy-propyl)-carbamic acid tert-butyl ester (98642-15-0) → 4-[2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyloxycarbonyl]benzoic acid (503442-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / DMAP; dicyclohexylcarbodiimide / CH₂Cl₂ / 0 - 20 °C

2: 93 percent / KMnO₄ / pyridine / 0 - 20 °C

With dmap; potassium permanganate; dicyclohexyl-carbodiimide; In pyridine; dichloromethane;

DOI:10.1016/S0040-4020(03)00466-6

upstream raw materials:

2-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonylaminomethyl)ethyl 4-formylbenzoate

4-Carboxybenzaldehyde

(3-tert-butoxycarbonylamino-2-hydroxy-propyl)-carbamic acid tert-butyl ester

Downstream raw materials:

C₄₅H₆₆N₆O₁₅

C₆₉H₁₀₂N₁₀O₂₁

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