5-Bromo-4-(hydroxymethyl)-2-methoxyphenol

Base Information

• Chemical Name: 5-Bromo-4-(hydroxymethyl)-2-methoxyphenol
• CAS No.: 52783-67-2
• Molecular Formula: C8H9BrO3
• Molecular Weight: 233.062
• DSSTox Substance ID: DTXSID50358407
• Wikidata: Q82138936
• Mol file: 52783-67-2.mol

Synonyms:5-bromo-4-(hydroxymethyl)-2-methoxyphenol;52783-67-2;HMS1589B17;Benzenemethanol, 2-bromo-4-hydroxy-5-methoxy-;SCHEMBL18475740;DTXSID50358407;AKOS015975130;CS-0378455;EN300-1895562;SR-01000265792;SR-01000265792-1

Chemical Property of 5-Bromo-4-(hydroxymethyl)-2-methoxyphenol

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 231.97351
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C(=C1)CO)Br)O

Technology Process of 5-Bromo-4-(hydroxymethyl)-2-methoxyphenol

There total 2 articles about 5-Bromo-4-(hydroxymethyl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

6-bromovanillin (60632-40-8) → 2-bromo-4-hydroxy-5-methoxybenzyl alcohol (52783-67-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; water; at 20 ℃; for 1h;

DOI:10.1021/jo062592v

Reference yield: 55.0%

4-<(tert-butyldimethylsilyl)oxy>-3-methoxybenzyl alcohol (113931-96-7) → 2-bromo-4-hydroxy-5-methoxybenzyl alcohol (52783-67-2)

Guidance literature:

With pyridinium hydrobromide perbromide; In methanol; for 2h; Ambient temperature;

DOI:10.1002/ardp.19953280402

Reference yield: 84.0%

2-bromo-4-hydroxy-5-methoxybenzyl alcohol (52783-67-2) → 2-bromo-5-methoxycyclohexa-2,5-diene-1,4-dione (23030-65-1)

Guidance literature:

With potassiuim nitrosodisulfonate; In chloroform; for 1h;

DOI:10.1016/S0040-4039(00)85150-3

upstream raw materials:

4-<(tert-butyldimethylsilyl)oxy>-3-methoxybenzyl alcohol

6-bromovanillin

Downstream raw materials:

2-bromo-5-methoxycyclohexa-2,5-diene-1,4-dione

6-bromovanillin

4,6-Di-hydroxymethyl-5-bromguajacol

2-bromo-5-methoxy-4-(methoxymethoxy)-1-(methoxymethoxymethyl)benzene