6-Bromovanillin

Base Information

• Chemical Name: 6-Bromovanillin
• CAS No.: 60632-40-8
• Molecular Formula: C8H7BrO3
• Molecular Weight: 231.046
• Hs Code.: 2913000090
• Mol file: 60632-40-8.mol

Synonyms:Vanillin,6-bromo- (6CI);2-Bromo-4-hydroxy-5-methoxybenzaldehyde;6-Bromovanillin;

Chemical Property of 6-Bromovanillin

Chemical Property:

• Vapor Pressure: 0.000115mmHg at 25°C
• Melting Point: 178 °C
• Refractive Index: 1.622
• Boiling Point: 326.2 °C at 760 mmHg
• PKA: 6.83±0.23(Predicted)
• Flash Point: 151.1 °C
• PSA: 46.53000
• Density: 1.653 g/cm³
• LogP: 1.97580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform, DCM, Ethyl Acetate

Purity/Quality:

98%, ^*data from raw suppliers

6-Bromovanillin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromovanillin is used in the synthesis of Carbidopa (C175915), an inhibitor of aromatic amino acid decarboxylase.

Technology Process of 6-Bromovanillin

There total 9 articles about 6-Bromovanillin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-acetoxy-2-bromo-5-methoxybenzaldehyde (52783-83-2) → 6-bromovanillin (60632-40-8)

Guidance literature:

With hydrogenchloride; water; at 90 ℃; for 4h;

DOI:10.1016/j.bmc.2011.09.023

Reference yield: 93.0%

vanillin acetate (881-68-5) → 6-bromovanillin (60632-40-8)

Guidance literature:

vanillin acetate; With bromine; potassium bromide; In water; at 20 ℃; for 10h;

With hydrogenchloride; at 90 ℃; for 10h; Further stages.;

DOI:10.1021/jo020171h

Reference yield: 76.0%

2-bromo-4-hydroxy-5-methoxybenzyl alcohol (52783-67-2) → 6-bromovanillin (60632-40-8)

Guidance literature:

With dipyridinium dichromate; In dichloromethane; for 36h; Ambient temperature;

DOI:10.1002/ardp.19953280402

upstream raw materials:

vanillin acetate

2-bromo-4,5-dimethoxybenzaldehyde

4-acetoxy-2-bromo-5-methoxybenzaldehyde

2-bromo-4-hydroxy-5-methoxybenzyl alcohol

Downstream raw materials:

5,6-dibromo-4-hydroxy-3-methoxybenzaldehyde

2-bromo-3-chloro-4-hydroxy-5-methoxy-benzaldehyde

4-benzoyloxy-2-bromo-5-methoxy-benzaldehyde

6-bromoferulic acid