N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine

Base Information

• Chemical Name: N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine
• CAS No.: 16018-52-3
• Molecular Formula: C12H13 N5 O
• Molecular Weight: 243.2645
• Mol file: 16018-52-3.mol

Synonyms:Guanidine,1-(4-hydroxy-6-methyl-2-pyrimidinyl)-3-phenyl- (8CI); Guanidine,N-(1,4-dihydro-6-methyl-4-oxo-2-pyrimidinyl)-N'-phenyl- (9CI)

Chemical Property of N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine

Chemical Property:

• Vapor Pressure: 3.47E-07mmHg at 25°C
• Boiling Point: 417.7°Cat760mmHg
• Flash Point: 206.4°C
• PSA: 93.92000
• Density: 1.34g/cm³
• LogP: 2.19510

Purity/Quality:

97% ^*data from raw suppliers

N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine

There total 8 articles about N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl acetoacetate (141-97-9) + 1-phenylbiguanide (102-02-3) → N-phenylguanidino-6-methylpyrimidinone + N-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N'-phenylguanidine (16018-52-3)

Guidance literature:

In ethanol;

Reference yield: 42.0%

ethyl acetoacetate (141-97-9) + 1-phenylbiguanide (102-02-3) → N-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N'-phenylguanidine (16018-52-3)

Guidance literature:

In methanol; at 18 - 25 ℃; for 30h;

DOI:10.1007/s11176-005-0218-x

Reference yield:

N-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyanamide (7152-19-4) + aniline hydrochloride (142-04-1,36663-09-9) → N-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-N'-phenylguanidine (16018-52-3)

Guidance literature:

With 2-ethoxy-ethanol; water;

upstream raw materials:

4-methyleneoxetan-2-one

1-phenylbiguanide

N-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyanamide

aniline hydrochloride

Downstream raw materials:

4,8-dimethyl-2-( phenylamino)-6H-pyrimido[1,2-a][1,3,5]-triazin-6-one

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