Butanamide, N-(2,4-dichloro-6-iodophenyl)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N- (methoxymethyl)-2-[(2-methoxyphenyl)methylene]-, (2E)-

Base Information

Chemical Name:Butanamide, N-(2,4-dichloro-6-iodophenyl)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N- (methoxymethyl)-2-[(2-methoxyphenyl)methylene]-, (2E)-
CAS No.:535932-42-4
Molecular Formula:C26H34Cl2INO4Si
Molecular Weight:650.456
Hs Code.:

Butanamide,
N-(2,4-dichloro-6-iodophenyl)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-
(methoxymethyl)-2-[(2-methoxyphenyl)methylene]-, (2E)-

Synonyms:

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Chemical Property of Butanamide, N-(2,4-dichloro-6-iodophenyl)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N- (methoxymethyl)-2-[(2-methoxyphenyl)methylene]-, (2E)-

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Technology Process of Butanamide, N-(2,4-dichloro-6-iodophenyl)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N- (methoxymethyl)-2-[(2-methoxyphenyl)methylene]-, (2E)-

There total 5 articles about Butanamide, N-(2,4-dichloro-6-iodophenyl)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N- (methoxymethyl)-2-[(2-methoxyphenyl)methylene]-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 107-30-2
chloromethyl methyl ether

: 535932-38-8
2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-3-(2-methoxyphenyl)acrylamide

: 535932-42-4
2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-3-(2-methoxyphenyl)-N-methoxymethylacrylamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ol034314d

Reference yield:

: 697-90-5
2,4-dichloro-6-iodoaniline

: 535932-42-4
2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-3-(2-methoxyphenyl)-N-methoxymethylacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: AlMe₃ / hexane; benzene / 0.75 h / 0 - 20 °C

1.2: 95 percent / hexane; benzene / 15 h / Heating

2.1: 98 percent / imidazole / dimethylformamide / 1 h / 20 °C

3.1: 87 percent / LiHMDS / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; trimethylaluminum; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ol034314d

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 535932-42-4
2-[2-(tert-butyldimethylsilanyloxy)ethyl]-N-(2,4-dichloro-6-iodophenyl)-3-(2-methoxyphenyl)-N-methoxymethylacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / toluene / 8 h / Heating

2.1: AlMe₃ / hexane; benzene / 0.75 h / 0 - 20 °C

2.2: 95 percent / hexane; benzene / 15 h / Heating

3.1: 98 percent / imidazole / dimethylformamide / 1 h / 20 °C

4.1: 87 percent / LiHMDS / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; trimethylaluminum; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene; benzene; 1.1: Wittig olefination;
DOI:10.1021/ol034314d