697-90-5

Usage

Uses

Used in Chemical Industry:
2,4-Dichloroaniline is used as a building block for the synthesis of various chemical products, such as herbicides, fungicides, and dyes, due to its reactivity and versatility in chemical reactions.
Used in Pharmaceutical Industry:
2,4-Dichloroaniline is used as an intermediate in the production of certain pharmaceutical compounds, contributing to the development of new drugs and medications.
Used in Research and Development:
2,4-Dichloroaniline is used as a laboratory reagent for conducting experiments and research, providing insights into its chemical properties and potential applications in various fields.
However, it is important to note that due to the potential health risks and environmental concerns associated with 2,4-dichloroaniline, its use is strictly regulated and monitored to minimize exposure and contamination.

InChI:InChI=1/C6H4Cl2IN/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2

Upstream product

• 554-00-7 2,4-Dichloroaniline 

Downstream Products

• 3032-81-3 3,5-dichloroiodobenzene 
• 535932-53-7 N-(2,4-dichloro-6-iodophenyl)-2-(2-hydroxyethyl)-3-(4-bromophenyl)acrylamide 
• 535932-37-7 N-(2,4-dichloro-6-iodophenyl)-2-(2-hydroxyethyl)-3-(2-methoxyphenyl)acrylamide 
• 5326-26-1 5,7-dichloro-2-phenyl-1H-indole 
• 1374581-30-2 4,6-dichloro-2-[4-(methylthio)phenyl]benzothiazole 
• 1374687-50-9 C₂₁H₁₆Cl₂N₂O₃S 
• 1382991-38-9 N-(2-(5,7-dichloro-2-(trimethylsilyl)-1H-indol-3-yl)ethyl)-3-(3-fluorobenzyl)benzamide 
• 1438414-73-3 2,4-dichloro-6-(2-phenylethynyl)benzeneamine 
• 1368045-58-2 4,6-dichloro-N-phenylbenzo[d]thiazol-2-amine 
• 4693-00-9 6,8-dichloro-2H-3,1-benzoxazine-2,4-dione 
• 73059-36-6 4,6-dichloro-2-phenylbenzo[d]thiazole 

Relevant academic research and scientific papers

Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases

New classes of CRTH2 antagonists, the pyridazine linker containing indole acetic acids, are described. The initial hit 1 had good potency but poor permeability, metabolic stability, and PK. Initial optimization led to compounds of type 2 with low oxidative metabolism but poor oral bioavailability. Poor permeability was identified as a liability for these compounds. Addition of a linker between the indole and diazine moieties afforded a series with good potency, low rates of metabolism, moderate permeability, and good oral bioavailability in rodents. 32 was identified as the development track candidate. It was potent in cell based, binding, and whole blood assays and exhibited good PK profile. It was efficacious in mouse models of contact hypersensitivity (1 mg/kg b.i.d.) and house dust (20 mg/kg q.d.) when dosed orally. In sheep asthma, administration at 1 mg/kg iv completely blocked the LAR and AHR and attenuated the EAR phase.

Synthesis of 3,1-Benzothiazines by Cyclisation of 2- Thioformylaminodiphenylacetylenes

2-Formylaminodiphenylacetylenes, obtained in excellent yield by Sonogashira coupling of (2-iodoaryl)formamides with phenylacetylene, were thionated with P4S10 in boiling THF to give 2-thioformylaminodiphenylacetylenes. These acetylenes were cyclised by DBU at ambient temperature to give (4Z)-4-benzylidene-4H-3,1-benzothiazines and small amounts of 2-phenylindoles. The structures of (4Z)-4-benzylidene-6,8-dichloro- 4H-3,1-benzothiazine and 3,5-dichloro-2-thioformylaminodiphenylacetylene were established by single crystal X-ray analysis.