Technology Process of 2H-Isoindole-2-acetic acid, .alpha.-butyl-1,3-dihydro-1,3-dioxo-, (.alpha.S)-
There total 1 articles about 2H-Isoindole-2-acetic acid, .alpha.-butyl-1,3-dihydro-1,3-dioxo-, (.alpha.S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
toluene;
at 110 ℃;
for 24h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
1.2: 4.5 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine; imidazole-1-sulfonyl azide hydrochloride / dichloromethane / 16 h / 40 °C
3.1: dirhodium tetraacetate / benzene / Reflux
With
imidazole-1-sulfonyl azide hydrochloride; dirhodium tetraacetate; triethylamine; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; dichloromethane; benzene;
DOI:10.3998/ark.5550190.0013.312
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; pyridine / dichloromethane / 20 h / 0 - 20 °C
1.2: 3 h / 20 °C
2.1: aluminum isopropoxide / isopropyl alcohol; toluene / 4 h / 100 °C
3.1: hydrazine hydrate / methanol / 3 h / 20 °C
4.1: triethylamine / acetonitrile / 20 h / Reflux
5.1: dichloromethane; methanol / Resolution of racemate
With
pyridine; oxalyl dichloride; hydrazine hydrate; aluminum isopropoxide; triethylamine;
In
methanol; dichloromethane; isopropyl alcohol; toluene; acetonitrile;
