6-Dehydrocortisol

Base Information

• Chemical Name: 6-Dehydrocortisol
• CAS No.: 600-99-7
• Molecular Formula: C21H28O5
• Molecular Weight: 360.444
• Mol file: 600-99-7.mol

Synonyms:11B,17ALPHA,20ALPHA,21-Tetrahydroxy-4-pregnen-3-one;4-pregnene-11B,17A,20A,21-tetrol-3-one;4-PREGNEN-11BETA,17ALPHA,20ALPHA,21-TETROL-3-ONE;REICHSTEIN'S SUBSTANCE 'EPI' 'E';20alpha-hydroxycortisol;REICHSTEIN'S EPI ''E'';

Chemical Property of 6-Dehydrocortisol

Chemical Property:

• Vapor Pressure: 3.59E-16mmHg at 25°C
• Melting Point: 239-241 °C
• Boiling Point: 586°C at 760 mmHg
• PKA: 12.44±0.70(Predicted)
• Flash Point: 322.2°C
• PSA: 94.83000
• Density: 1.31g/cm³
• LogP: 1.55760
• Storage Temp.: Refrigerator
• Solubility.: Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

6-Dehydrocortisol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6-Dehydrocortisol (Hydrocortisone EP Impurity E) is a metabolite of Cortisol (H714615), a glucocorticoid, produced by the zona fasciculata of the adrenal gland. 6-Dehydrocortisol was used in the identification of Trp-371 as the main site of specific photoaffinity labeling of corticosteroid binding globulin. 6-Dehydrocortisol is a metabolite of Cortisol (H714615), a glucocorticoid, produced by the zona fasciculata of the adrenal gland. 6-Dehydrocortisol was used in the identification of Trp-371 as the main site of specific photoaffinity labeling of corticosteroid binding globulin.

Technology Process of 6-Dehydrocortisol

There total 2 articles about 6-Dehydrocortisol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

21-acetoxy-17-hydroxy-pregna-4,6-diene-3,11,20-trione-3,20-disemicarbazone (115097-13-7) → 11β,17,21-trihydroxy-pregna-4,6-diene-3,20-dione (600-99-7)

Guidance literature:

With sodium tetrahydroborate; anschliessend mit Brenztaubensaeure;

DOI:10.1021/ja01559a074

Reference yield:

6-dehydroprogesterone (1162-56-7) → 11β,17,21-trihydroxy-pregna-4,6-diene-3,20-dione (600-99-7)

Guidance literature:

in Rinder-Nebennieren;

Reference yield:

11β,17,21-trihydroxy-pregna-4,6-diene-3,20-dione (600-99-7) + acetic anhydride (108-24-7) → 6,7-dehydrocortisol 21-acetate (21940-45-4)

Guidance literature:

With pyridine;

upstream raw materials:

6-dehydroprogesterone

21-acetoxy-17-hydroxy-pregna-4,6-diene-3,11,20-trione-3,20-disemicarbazone

Downstream raw materials:

6,7-dehydroprednisolone

6,7-dehydrocortisol 21-acetate