6,7-Dehydro Prednisolone

Base Information

• Chemical Name: 6,7-Dehydro Prednisolone
• CAS No.: 2427-64-7
• Molecular Formula: C₂₁H₂₆O₅
• Molecular Weight: 358.434
• Mol file: 2427-64-7.mol

Synonyms:Pregna-1,4,6-triene-3,20-dione,11b,17,21-trihydroxy- (6CI,7CI,8CI);NSC 12882

Chemical Property of 6,7-Dehydro Prednisolone

Chemical Property:

• Vapor Pressure: 2.02E-16mmHg at 25°C
• Melting Point: 218-222°C
• Boiling Point: 590.8°C at 760 mmHg
• PKA: 12.43±0.70(Predicted)
• Flash Point: 325.1°C
• PSA: 94.83000
• Density: 1.33g/cm³
• LogP: 1.33360
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: Dioxane (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly, Hea

Purity/Quality:

97% ^*data from raw suppliers

6-DehydroPrednisolone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Dehydro Prednisolone (Prednisolone EP Impurity H) is a metabolite of Prednisone (P703780).

Technology Process of 6,7-Dehydro Prednisolone

There total 6 articles about 6,7-Dehydro Prednisolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrocortisone acetate (50-03-3) → 6,7-dehydroprednisolone (2427-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrachloro-<1,4>benzoquinone

With chloranil;

DOI:10.1021/ja01562a058

Reference yield:

21-acetoxy-17-hydroxy-pregna-4,6-diene-3,11,20-trione-3,20-disemicarbazone (115097-13-7) → 6,7-dehydroprednisolone (2427-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / anschliessend mit Brenztaubensaeure

2: mit Hilfe von Bacillus sphaericus

With sodium tetrahydroborate;

DOI:10.1021/ja01559a074

Reference yield:

11β,17,21-trihydroxy-pregna-4,6-diene-3,20-dione (600-99-7) → 6,7-dehydroprednisolone (2427-64-7)

Guidance literature:

mit Hilfe von Bacillus sphaericus;

DOI:10.1021/ja01559a074

upstream raw materials:

11β,17,21-trihydroxy-pregna-4,6-diene-3,20-dione

21-acetoxy-11β,17α-dihydroxypregna-1,4,6-triene-3,20-dione

hydrocortisone acetate

21-acetoxy-17-hydroxy-pregna-4,6-diene-3,11,20-trione-3,20-disemicarbazone