6-Dehydrocortisol Acetate

Base Information

• Chemical Name: 6-Dehydrocortisol Acetate
• CAS No.: 21940-45-4
• Molecular Formula: C₂₃H₃₀O₆
• Molecular Weight: 402.488
• Mol file: 21940-45-4.mol

Synonyms:

Chemical Property of 6-Dehydrocortisol Acetate

Chemical Property:

• Melting Point: 223-226 °C (decomp)(Solv: acetone (67-64-1); ethyl ether (60-29-7))
• Boiling Point: 593.7±50.0 °C(Predicted)
• PKA: 12.39±0.70(Predicted)
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

6-DehydrocortisolAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6-Dehydrocortisol Acetate, an acetylated derivative of 6-Dehydrocortisol (D229145), is a substituted corticosteroid with antiinflammatory activity.

Technology Process of 6-Dehydrocortisol Acetate

There total 8 articles about 6-Dehydrocortisol Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

hydrocortisone acetate (50-03-3) → 6,7-dehydrocortisol 21-acetate (21940-45-4)

Guidance literature:

With chloranil; In tert-butyl alcohol; Heating;

Reference yield:

21-acetoxy-11β-hydroxy-pregna-4,6,17(20)c-trien-3-one (116956-81-1) → 6,7-dehydrocortisol 21-acetate (21940-45-4)

Guidance literature:

With dihydrogen peroxide; 4-methylmorpholine N-oxide;

Reference yield:

6-dehydroprogesterone (1162-56-7) → 6,7-dehydrocortisol 21-acetate (21940-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: in Rinder-Nebennieren

2: pyridine

With pyridine;

upstream raw materials:

hydrocortisone acetate

21-acetoxy-11β-hydroxy-pregna-4,6,17(20)c-trien-3-one

11β,17,21-trihydroxy-pregna-4,6-diene-3,20-dione

acetic anhydride

Downstream raw materials:

21-acetoxy-11β,17α-dihydroxypregna-1,4,6-triene-3,20-dione

Refernces

• 1、 Mikola, Heikki,Miettinen, Paeivi. "Preparation of europium-labeled derivatives of cortisol for time-resolved fluoroimmunoassays". . p. 17 - 21. Retrieved 1991.
• 2、 Barton, Derek H.R.,Lister-James, John,Hesse, Robert H.,Pechet, Maurice M.,Rozen, Shlomo. "Electrophilic Fluorination of Some Steroidal α,β-Unsaturated Ketones". . p. 1105 - 1110. Retrieved 2007/10/02.