Silane, (1,1-dimethylethyl)dimethyl[(2R)-3,3,3-trifluoro-2-methoxy-2-phenylprop oxy]-

Base Information

• Chemical Name: Silane, (1,1-dimethylethyl)dimethyl[(2R)-3,3,3-trifluoro-2-methoxy-2-phenylprop oxy]-
• CAS No.: 537695-82-2
• Molecular Formula: C16H25F3O2Si
• Molecular Weight: 334.454
• Mol file: 537695-82-2.mol

Synonyms:

Chemical Property of Silane, (1,1-dimethylethyl)dimethyl[(2R)-3,3,3-trifluoro-2-methoxy-2-phenylprop oxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Silane, (1,1-dimethylethyl)dimethyl[(2R)-3,3,3-trifluoro-2-methoxy-2-phenylprop oxy]-

There total 3 articles about Silane, (1,1-dimethylethyl)dimethyl[(2R)-3,3,3-trifluoro-2-methoxy-2-phenylprop oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(R)-3-(tert-butyldimethylsilyloxy)-1,1,1-trifluoro-2-phenylpropan-2-ol (537695-75-3) + methyl iodide (74-88-4) → (R)-3-(tert-butyldimethylsilyloxy)-1,1,1-trifluoro-2-methoxy-2-phenylpropane (537695-82-2)

Guidance literature:

With potassium tert-butylate; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1016/S0957-4166(03)00023-5

Reference yield:

3,3,3-trifluoro-2-phenylpropene (384-64-5) → (R)-3-(tert-butyldimethylsilyloxy)-1,1,1-trifluoro-2-methoxy-2-phenylpropane (537695-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / AD-mix β / 2-methyl-propan-2-ol; H2O / 2 h / 20 °C

2: 94 percent / DMAP; Et₃N / CH₂Cl₂ / 2 h / 20 °C

3: 94 percent / t-BuOK / acetonitrile / 12 h / 20 °C

With dmap; potassium tert-butylate; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; In dichloromethane; water; acetonitrile; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation;

DOI:10.1016/S0957-4166(03)00023-5

Reference yield:

(-)-(2R)-3,3,3-trifluoro-2-phenylpropane-1,2-diol (159383-84-3) → (R)-3-(tert-butyldimethylsilyloxy)-1,1,1-trifluoro-2-methoxy-2-phenylpropane (537695-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / DMAP; Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 94 percent / t-BuOK / acetonitrile / 12 h / 20 °C

With dmap; potassium tert-butylate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1016/S0957-4166(03)00023-5

upstream raw materials:

(R)-3-(tert-butyldimethylsilyloxy)-1,1,1-trifluoro-2-phenylpropan-2-ol

methyl iodide

3,3,3-trifluoro-2-phenylpropene

(-)-(2R)-3,3,3-trifluoro-2-phenylpropane-1,2-diol

Downstream raw materials:

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

(R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanol