1-Piperidinecarboxylic acid, 4-[4-[[[2-[2-[(1Z)-2-(acetylamino)-3-methoxy-3-oxo-1-propenyl]-5-cyano phenoxy]ethyl]amino]carbonyl]phenoxy]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[4-[[[2-[2-[(1Z)-2-(acetylamino)-3-methoxy-3-oxo-1-propenyl]-5-cyano phenoxy]ethyl]amino]carbonyl]phenoxy]-, 1,1-dimethylethyl ester
CAS No.:538335-90-9
Molecular Formula:C32H38N4O8
Molecular Weight:606.676
Hs Code.:

1-Piperidinecarboxylic acid,
4-[4-[[[2-[2-[(1Z)-2-(acetylamino)-3-methoxy-3-oxo-1-propenyl]-5-cyano
phenoxy]ethyl]amino]carbonyl]phenoxy]-, 1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-[4-[[[2-[2-[(1Z)-2-(acetylamino)-3-methoxy-3-oxo-1-propenyl]-5-cyano phenoxy]ethyl]amino]carbonyl]phenoxy]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-[4-[[[2-[2-[(1Z)-2-(acetylamino)-3-methoxy-3-oxo-1-propenyl]-5-cyano phenoxy]ethyl]amino]carbonyl]phenoxy]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-[4-[[[2-[2-[(1Z)-2-(acetylamino)-3-methoxy-3-oxo-1-propenyl]-5-cyano phenoxy]ethyl]amino]carbonyl]phenoxy]-, 1,1-dimethylethyl ester

There total 10 articles about 1-Piperidinecarboxylic acid, 4-[4-[[[2-[2-[(1Z)-2-(acetylamino)-3-methoxy-3-oxo-1-propenyl]-5-cyano phenoxy]ethyl]amino]carbonyl]phenoxy]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 162046-56-2
4-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid

: 3-[4-cyano-2-(2-aminoethoxy)phenyl]-2-acetamidoacrylic acid methyl ester hydrochloride

: 538335-90-9
methyl 2-acetamido-3-[2-[2-[4-(1-tert-butoxycarbonyl-4-piperidyloxy)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm020485x

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 538335-90-9
methyl 2-acetamido-3-[2-[2-[4-(1-tert-butoxycarbonyl-4-piperidyloxy)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 °C

2: 92 percent / aq. NaOH / ethanol / 72 h

3: 85 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm020485x

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 538335-90-9
methyl 2-acetamido-3-[2-[2-[4-(1-tert-butoxycarbonyl-4-piperidyloxy)benzoylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0 °C

2: 92 percent / aq. NaOH / ethanol / 72 h

3: 85 percent / triethylamine; 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm020485x