1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[4-[2-(bromomethyl)-1H-imidazol- 1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

Base Information

Chemical Name:1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[4-[2-(bromomethyl)-1H-imidazol- 1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-
CAS No.:540510-51-8
Molecular Formula:C22H14BrF4N7O2
Molecular Weight:564.296
Hs Code.:

1H-Pyrazole-5-carboxamide,
1-(3-amino-1,2-benzisoxazol-5-yl)-N-[4-[2-(bromomethyl)-1H-imidazol-
1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[4-[2-(bromomethyl)-1H-imidazol- 1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

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Technology Process of 1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[4-[2-(bromomethyl)-1H-imidazol- 1-yl]-2-fluorophenyl]-3-(trifluoromethyl)-

There total 10 articles about 1H-Pyrazole-5-carboxamide, 1-(3-amino-1,2-benzisoxazol-5-yl)-N-[4-[2-(bromomethyl)-1H-imidazol- 1-yl]-2-fluorophenyl]-3-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540510-38-1
N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

: 540510-51-8
2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(2-bromomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm0497949

Reference yield:

: 540510-47-2
1-(4-amino-3-fluorophenyl)-2-hydroxymethylimidazole

: 540510-51-8
2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(2-bromomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / Et₃N / dimethylformamide / 12 h / 20 °C

2: 0.48 g / DMAP / CH₂Cl₂ / 12 h / 20 °C

3: acetohydroxamic acid; aq. K₂CO₃ / dimethylformamide / 12 h / 20 °C

4: Bu₄NF / tetrahydrofuran / 1 h / 20 °C

5: 0.18 g / PBr₃ / CH₂Cl₂ / 12 h / 20 °C

With dmap; acetylhydroxamic acid; tetrabutyl ammonium fluoride; phosphorus tribromide; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497949

Reference yield:

: 540510-48-3
1-(4-amino-3-fluorophenyl)-2-(tert-butyldimethylsilyloxymethyl)imidazole

: 540510-51-8
2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(2-bromomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 0.48 g / DMAP / CH₂Cl₂ / 12 h / 20 °C

2: acetohydroxamic acid; aq. K₂CO₃ / dimethylformamide / 12 h / 20 °C

3: Bu₄NF / tetrahydrofuran / 1 h / 20 °C

4: 0.18 g / PBr₃ / CH₂Cl₂ / 12 h / 20 °C

With dmap; acetylhydroxamic acid; tetrabutyl ammonium fluoride; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497949