N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:540510-38-1
Molecular Formula:C₂₂H₁₅F₄N₇O₃
Molecular Weight:501.4
Hs Code.:

Synonyms:N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 10 articles about N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540510-50-7
N-[4-[(2-t-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

: 546-88-3
acetylhydroxamic acid

: 540510-38-1
N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

: 540510-50-7
N-[4-[(2-t-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

: 540510-38-1
N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm0497949

Reference yield:

: 540510-47-2
1-(4-amino-3-fluorophenyl)-2-hydroxymethylimidazole

: 540510-38-1
N-[4-(2-[hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / Et₃N / dimethylformamide / 12 h / 20 °C

2: 0.48 g / DMAP / CH₂Cl₂ / 12 h / 20 °C

3: acetohydroxamic acid; aq. K₂CO₃ / dimethylformamide / 12 h / 20 °C

4: Bu₄NF / tetrahydrofuran / 1 h / 20 °C

With dmap; acetylhydroxamic acid; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497949